Background: It is uncommon for emergency physicians to discover a patient with circulatory failure resulting from chronic diarrhea.
Objectives: We describe McKittrick-Wheelock syndrome, a rare disorder characterized by volume and electrolyte depletion and caused by colonic neoplasm.
Case Report: The case of a 30-year-old woman who came to the Emergency Department with hypovolemic shock, hyponatremia, and hypokalemia with a background of chronic diarrhea is reported. The hypokalemia and dehydration were refractory to aggressive replacement therapy. Her condition was the result of fluid and electrolyte hypersecretion caused by a colonic adenocarcinoma and colonic polyposis. Surgical removal of the colon and subsequent volume and electrolyte replacement therapy resulted in complete recovery.
Conclusion: This case is presented to increase awareness among emergency physicians of the rare disorder of McKittrick-Wheelock syndrome.
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