AI Article Synopsis
- The H1N1 swine-origin influenza virus (S-OIV) is a significant global health issue requiring better understanding of its relationships with host organisms for effective control.
- Two human monoclonal antibody fragments that neutralize various H1N1 strains, including S-OIV, were cloned from a patient and showed effectiveness at very low concentrations.
- The findings suggest that exposure to prior H1N1 strains can generate protective antibodies against S-OIV, and the genes for these antibodies could help create safe and effective treatments for this infection.
Article Abstract
The new H1N1 swine-origin influenza virus (S-OIV) strain is a global health problem. The elucidation of the virus-host relationship is crucial for the control of the new infection. Two human monoclonal antibody Fab fragments (HMab) neutralizing the novel H1N1 influenza strain at very low concentrations were cloned before the emergence of S-OIV from a patient who had a broad-range H1N1 serum neutralizing activity. The two HMabs neutralized all tested H1N1 strains, including S-OIV and a swine strain with IC(50) ranging from 2 to 7 microg/ml. Data demonstrate that infection with previously circulating H1N1 strains can elicit antibodies neutralizing S-OIV. Finally, the human genes coding for the neutralizing HMabs could be used for generating full human monoclonal IgGs that can be safely administered being potentially useful in the prophylaxis and the treatment of this human infection.
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| http://dx.doi.org/10.1016/j.virol.2009.12.014 | DOI Listing |
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