We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [(123)I]beta-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854241 | PMC |
| http://dx.doi.org/10.1016/j.nbd.2010.01.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.
Environ Health Perspect
December 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, Texas, USA.
Background: Increasing evidence supports an association of endocrine-disrupting chemical (EDC) exposures with adverse biological effects in humans and wildlife. Recent studies reveal that health consequences of environmental exposures may persist or emerge across generations. This creates a dual conundrum: that we are exposed to contemporary environmental chemicals overlaid upon the inheritance of our ancestors' exposure profiles.
View Article and Find Full Text PDFTwo Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin.
Environ Health Perspect
December 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, Texas, USA.
Background: Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds that interfere with the normal function of the endocrine system and are linked to direct and inherited adverse effects in both humans and wildlife. Legacy EDCs such as polychlorinated biphenyls (PCBs) are no longer used yet remain detectable in biological specimens around the world; concurrently, we are exposed to newer EDCs like the fungicide vinclozolin (VIN). This combination of individuals' direct environmental chemical exposures and any heritable changes caused by their ancestors' chemical exposures leads to a layered pattern of both direct and ancestrally inherited exposures that might have cumulative effects over generations.
View Article and Find Full Text PDFRisk of autism spectrum disorder at 18 months of age is associated with prenatal level of polychlorinated biphenyls exposure in a Japanese birth cohort.
Sci Rep
December 2024
Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-hiroshima, Hiroshima, 739-8527, Japan.
Prenatal exposure to polychlorinated biphenyls (PCBs) has a detrimental effect on early cognitive development. Based on these observations, some researchers suggested that prenatal exposure to PCB may be an environmental cause of autism spectrum disorder (ASD). To investigate the potential link between prenatal exposure to PCB, we analyzed the link between the level of prenatal PCB exposure and ASD risk evaluated at 18 months of age and behavioral problems at 5 years old based on longitudinal birth cohort data collected in urban areas in Japan based on the data from 115 mother-infant pairs.
View Article and Find Full Text PDFAccumulation of lipophilic and proteinophilic halogenated organic pollutants (HOPs) in the different types of feathers of laying hens.
J Hazard Mater
December 2024
State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control, Guangzhou 510640, China; CAS Center for Excellence in Deep Earth Science, Guangzhou 510640, China.
This study investigated the bioaccumulation of halogenated organic pollutants (HOPs) in three types of feathers from laying hens through exposure experiments. The HOPs included lipophilic polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), as well as proteinophilic perfluoroalkyl carboxylic acids (PFCAs). Concentrations of PCBs, PBDEs, and short-chain PFCAs (≤8) were significantly higher in the body feathers than in the primary feathers, while long-chain PFCAs (>8) showed no significant differences among primary, tail, and body feathers.
View Article and Find Full Text PDFExposure to the Polychlorinated biphenyl mixture Aroclor 1254 elicits neurological and cardiac developmental effects in early life stage zebrafish (Danio rerio).
Chemosphere
January 2025
University of North Texas, Department of Biological Sciences and Advanced Environmental Research Institute, Denton, TX, 76203, USA. Electronic address:
The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!