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Non-Meckel Ileal Diverticulum Incarcerated Within a Strangulated Inguinal Hernia: A Case Report.
Cureus
December 2024
Upper Gastrointestinal Surgery, North Manchester General Hospital, Manchester, GBR.
Non-Meckel small bowel diverticula, particularly ileal diverticula, are rare, especially when incarcerated within an inguinal hernia sac. This case involves an 80-year-old man who presented with a newly noticed tender, irreducible lump in his left groin, accompanied by symptoms of bowel obstruction such as inability to pass flatus and vomiting. His medical history included a previous right inguinal hernia repair.
View Article and Find Full Text PDFCancer immunotherapy using engineered cytotoxic effector cells has demonstrated significant potential. The limited spatial complexity of existing models, however, poses a challenge to mechanistic studies attempting to approve existing approaches of effector cell-mediated cytotoxicity within a three-dimensional, solid tumor-like environment. To gain additional experimental control, we developed an approach for constructing three-dimensional (3D) culture models using smart polymers that form temperature responsive hydrogels.
View Article and Find Full Text PDFEffects of endophytes on early growth and ascorbate metabolism in .
Front Plant Sci
December 2024
Department of Plant Biology, Rutgers University, New Brunswick, NJ, United States.
Understanding the early interactions between plants and endophytes will contribute to a more systematic approach to enhancing endophyte-mediated effects on plant growth and environmental stress resistance. This study examined very early growth and ascorbate metabolism after seed treatment of with three different endophytes. The three endophytes used were pb1(Bapb1), (Ml) and SLB4 (SLB4).
View Article and Find Full Text PDFTherapeutic deep eutectic solvent with saponin, optimized through response surface methodology, exert potent in vivo antimicrobial effects against Pseudomonas aeruginosa.
Sci Rep
November 2024
Department of Chemistry, School of Chemical & Biotechnology, Shanmugha Arts, Science, Technology & Research Academy (SASTRA) Deemed University, Thanjavur, 613 401, Tamil Nadu, India.
Therapeutic deep eutectic solvents (THEDES) are a type of deep eutectics that can be used as active pharmaceutical ingredients (APIs) by enhancing the drug bioavailability, by increasing the solubility of APIs in aqueous solutions or by increasing their permeability through biological barriers. In this study, we demonstrate the utility of designer THEDES, based on Quillaja Saponin (SAP), a triterpene natural product to unravel the antimicrobial potential of such THEDES. THEDES were prepared by gently mixing and heating five different α- hydroxy acids- malic, citric, tartaric, glycolic, lactic acids and SAP with water as a third component in the THEDES.
View Article and Find Full Text PDFOn the Billefjorden fault zone in Garmdalen, central Spitsbergen: implications for the mapping of major fault zones during geological fieldwork and for the tectonic history of Svalbard.
Open Res Eur
October 2024
National Agency of Hydrocarbon, Bogota, Cundinamarca, 111321, Colombia.
Background: The present contribution reexamines the geometry of a segment of a presumably long-lived fault in Svalbard, the Balliolbreen Fault segment of the Billefjorden Fault Zone, along which presumably two basement terranes of Svalbard accreted in the early-mid Paleozoic after thousands of kilometers strike-slip displacement.
Methods: We performed structural fieldwork to Billefjorden in central Spitsbergen and interpreted satellite images.
Results: Field observations demonstrate that the Balliolbreen Fault formed as a top-west thrust fault in the early Cenozoic and that weak sedimentary units such as shales of the Lower Devonian Wood Bay Formation and coals of the uppermost Devonian-Mississippian Billefjorden Group partitioned deformation, resulting in significant contrast in deformation intensity between stratigraphic units.
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