AI Article Synopsis
- Spectinabilin is a rare metabolite that belongs to a group called nitrophenyl-substituted polyketides.
- The researchers successfully cloned and expressed the spectinabilin gene cluster from the bacterium Streptomyces spectabilis.
- Interestingly, this gene cluster is more closely related to another gene cluster for aureothin than to the previously known spectinabilin cluster from Streptomyces orinoci, and they regulate their functions differently despite their similarities.
Article Abstract
Spectinabilin is a rare nitrophenyl-substituted polyketide metabolite. Here we report the cloning and heterologous expression of the spectinabilin gene cluster from Streptomyces spectabilis. Unexpectedly, this gene cluster is evolutionarily closer to the aureothin gene cluster than to the spectinabilin gene cluster from Streptomyces orinoci. Moreover, the two nearly identical spectinabilin gene clusters use a distinctly different regulation mechanism.
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| http://dx.doi.org/10.1039/b923177c | DOI Listing |
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