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Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study.
Blood
March 2025
Sanofi, Cambridge, Massachusetts, United States.
Rilzabrutinib is a covalent, reversible BTK inhibitor with multiple mechanisms targeting key immune thrombocytopenia (ITP) disease pathophysiology. The phase 3 LUNA3 study in previously treated adults with persistent/chronic ITP evaluated oral rilzabrutinib 400 mg bid (n=133) vs placebo (n=69) for 24 weeks. At baseline overall, median age was 47 years (range, 18-80), 63% female, 7.
View Article and Find Full Text PDFForecasting invasive mosquito abundance in the Basque Country, Spain using machine learning techniques.
Parasit Vectors
March 2025
M3A, Basque Center for Applied Mathematics, Mazarredo 14, 48009, Bilbao, Bizkaia, Spain.
Background: Mosquito-borne diseases cause millions of deaths each year and are increasingly spreading from tropical and subtropical regions into temperate zones, posing significant public health risks. In the Basque Country region of Spain, changing climatic conditions have driven the spread of invasive mosquitoes, increasing the potential for local transmission of diseases such as dengue, Zika, and chikungunya. The establishment of mosquito species in new areas, coupled with rising mosquito populations and viremic imported cases, presents challenges for public health systems in non-endemic regions.
View Article and Find Full Text PDFCapturing sexual orientation and gender identity information in electronic medical records to inform the person-centred care of sexual and gender minority people.
BMC Public Health
March 2025
EMR Team, The Royal Melbourne Hospital, Parkville, VIC, Australia.
Background: The healthcare disparities of sexual and gender minority (SGM) people are globally recognised. Research from the United States has advocated for sexual orientation and gender identity (SOGI) information capture via the electronic medical record (EMR) to support the generation of knowledge regarding SGM people's healthcare needs and the appropriate care for this population. In November 2022, The Royal Melbourne Hospital (RMH) enabled the SOGI capture EMR functionality.
View Article and Find Full Text PDFGlobal output of clinical application research on artificial intelligence in the past decade: a scientometric study and science mapping.
Syst Rev
March 2025
School of Nursing, Beijing University of Chinese Medicine, Beijing, China.
Background: Artificial intelligence (AI) has shown immense potential in the field of medicine, but its actual effectiveness and safety still need to be validated through clinical trials. Currently, the research themes, methodologies, and development trends of AI-related clinical trials remain unclear, and further exploration of these studies will be crucial for uncovering AI's practical application potential and promoting its broader adoption in clinical settings.
Objective: To analyze the current status, hotspots, and trends of published clinical research on AI applications.
Comparison of remimazolam tosylate and propofol in hemodynamic stability, postoperative cognitive function, and recovery in general anesthesia combined with regional nerve blocks: a retrospective cohort study.
BMC Anesthesiol
March 2025
Anesthesia and Surgery Center, Ziyang Central Hospital, No. 66, Rende West Road, Yanjiang District, Ziyang City, Sichuan Province, 641300, China.
Background: General anesthesia (GA) combined with regional anesthesia (RA) is commonly used to enhance perioperative analgesia and hemodynamic stability. This study aimed to compare the hemodynamic effects and postoperative cognitive function between remimazolam tosylate and propofol in patients undergoing GA combined with RA.
Methods: A retrospective cohort study was conducted on 4408 patients who underwent elective upper or lower limb surgeries at our institution from January 2020 to June 2024.
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