AI Article Synopsis
- The study aimed to understand factors affecting the severity and treatment strategies for severe acute pancreatitis (SAP) with early organ dysfunction.
- Out of 167 patients treated, 68 experienced early organ dysfunction, predominantly affecting the cardiovascular, lung, and kidney systems, with significant links to age and APACHE II scores indicating poorer outcomes.
- Early surgical intervention may improve prognosis, highlighting the need to evaluate organ dysfunction levels before the onset of infected necrosis using the SOFA score.
Article Abstract
Objective: To investigate the severity related influencing factor and treatment strategy of severe acute pancreatitis with early organ dysfunction.
Methods: From July 2007 to December 2008, 167 patients with severe acute pancreatitis were treated in the Surgical Department of Ruijin Hospital. The relationships between the happening of early organ dysfunction and outcome of the patients were observed, with operative or nonoperative treatment strategy.
Results: Among 167 patients, 68 patients have early organ dysfunction, in which 39 with single organ dysfunction and 29 with multiple organ dysfunction. The early organ dysfunction were involved in 47.1% in cardiovascular system, 35.3% in lung and 29.4% in kidney. Aging (P < 0.05) and higher APACHE II score (P < 0.05) predicted a poor prognosis, which were benefit from early operation.
Conclusions: The mortality of the patients with SAP is related to age, and the degree of organ dysfunction as well. In the first phase of the disease, the selection of operation depends on the trends and the degree of early organ dysfunction before infected necrosis happens, with the aid of SOFA score as a scale.
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