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Ablation of IGFBP5 expression alleviates neurogenic erectile dysfunction by inducing neurovascular regeneration.
Investig Clin Urol
January 2025
National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine, Incheon, Korea.
Purpose: To investigate the therapeutic potential of eliminating insulin-like growth factor-binding protein 5 (IGFBP5) expression in improving erectile function in mice with cavernous nerve injury (CNI)-induced erectile dysfunction (ED).
Materials And Methods: Eight-week-old male C57BL/6 mice were divided into four groups: a sham-operated group and three CNI-induced ED groups. The CNI-induced ED groups were treated with intracavernous injections 3 days before the CNI procedure.
Dual-responsive stem cell microspheres modified with BDNF for enhanced neural repair in diabetic erectile dysfunction.
J Control Release
January 2025
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Institute of Urology, Beijing Municipal Health Commission, Beijing 100050, China. Electronic address:
We previously established an effective method to ameliorate erectile dysfunction (ED) using intracavernous injection (ICI) of mesenchymal stem cell (MSC) microspheres. However, the expression of a key neurotrophic factor, brain-derived neurotrophic factor (BDNF), was low in both MSCs and MSC microspheres, restricting the associated neural repair. Based on the hypoxia and oxidative stress microenvironments within cell spheroids and lesion areas, BDNF-expressing nanocomplexes that are dual-responsive to hypoxia and reactive oxygen species were designed to modify MSCs, achieving high BDNF expression in MSC spheroids.
View Article and Find Full Text PDFIntroduction: Recurrent priapism is a rare variant of ischemic priapism that involves recurrent erections typically lasting less than 4 h. The primary goal of treatment is to prevent future episodes, with options ranging from pharmacological treatments to various surgeries.
Case Presentation: A 38-year-old man experienced multiple episodes of priapism that were refractory to angioembolization of an arteriocavernous fistula and oral treatment with Cetirizine and Bicalutamide.
Persistent Penile Erection Following Spinal or General Anesthesia During Pediatric Hypospadias Repair: A Case Report.
Cureus
October 2024
Pediatric Surgery, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Article Synopsis
- * Multiple initial interventions, including medications and cold compresses, failed to resolve the persistent PE before the surgery could proceed.
- * The successful resolution of PE was achieved with an intracavernous injection of phenylephrine, demonstrating its effectiveness and the need for adaptability in managing such complications in pediatric surgeries.
Efficacy and safety of platelet-rich plasma intracavernous injection for patients with erectile dysfunction: A systematic review, meta-analysis, and meta-regression.
Asian J Urol
October 2024
Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia.
Objective: Intracavernous injection might be offered to patients with erectile dysfunction (ED) who did not respond to the first-line oral treatment. Platelet-rich plasma (PRP) might offer improvement in erectile function since it contains numerous growth factors. This study aimed to evaluate the efficacy and safety of PRP intracavernous injection for patients with ED.
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