Background: Extranodal nasal-type natural killer (NK)/T-cell lymphoma (NKTL) is a rare, but distinct clinical entity in Asian populations. However, it is not uncommon for NKTL to be belatedly or postoperatively diagnosed because radiologists are not familiar with its radiological features.
Purpose: To investigate the computed tomography (CT) findings in patients with extranodal nasal-type NKTL involving the head and neck.
Material And Methods: Twenty-nine patients (18 male, 11 female; mean age 51.5 years) with pathologically proven extranodal nasal-type NKTL were enrolled in this study. Two head-and-neck radiologists retrospectively evaluated the CT scans with special attention to the primary site, the extent of involvement, and patterns of the lesions (i.e., morphologic features, ulceration or necrosis, and bone destruction).
Results: The cases of nasal-type NKTL consisted of primary tumors arising from the sinonasal cavity in 13 patients (45%), the naso/oropharynx in three patients (10%), and simultaneous involvement in the nasal cavity and naso/oropharynx in 13 patients (45%). Fourteen patients (48%) showed tumor extension into adjacent structures. Of the 26 patients with involvement of the nasal cavity, 18 (69%) presented with an infiltrative pattern, seven (27%) with a polypoid pattern, and one (4%) with a combined pattern. Areas of necrosis within the tumor were observed in six patients (21%), bone destruction in five (17%), and regional lymphadenopathies in two (7%).
Conclusion: Extranodal NKTL may be initially suggested by CT findings in the head and neck. Clinicians should consider these findings indicative of the possibility of NKTL, and should perform a histopathologic confirmation to establish a diagnosis.
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http://dx.doi.org/10.3109/02841850903476572 | DOI Listing |
Eur Radiol
January 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Purpose: To evaluate the prognostic value of interim [F]Fluorodeoxyglucose positron emission tomography/computed tomography ([F]FDG PET/CT) after immunotherapy-based systemic therapies in extranodal natural killer/T-cell lymphoma (ENKTL).
Patients And Methods: We retrospectively recruited 133 newly diagnosed nasal-type ENKTL patients who underwent interim [F]FDG PET/CT scans after 2-4 cycles of immunotherapy-based treatments. Interim PET/CT was interpreted by maximum standardized uptake value (SUV), Deauville 5-point scale (DS), and early treatment response.
J Asthma Allergy
January 2025
Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Background: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a rare, highly invasive Epstein-Barr virus associated hematological malignant tumor with an unfavorable prognosis. Although ENKTCL-NT has been previously reported, no relevant article has provided an intuitive, progressive series of schematic illustrations of the rapid progression of facial ulcers.
Objective: This article reports a serious case of ENKTCL-NT that involved the entire process from onset to death.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an223000, China.
Transl Oncol
January 2025
Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China. Electronic address:
Background: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a malignant tumor harboring a poor prognosis and unsatisfactory treatment outcomes. This study was performed to explore the pathogenesis and exact etiology of ENKTL. Methods Bioinformatic analysis was conducted to investigate the expression of SIRT5 and glucose-6-phosphate isomerase (GPI), as well their correlation with ENKTL overall survival.
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