AI Article Synopsis
- The study focuses on extracting compounds from the Indonesian Streptomyces sp. ICBB8198, highlighting both known and new antibiotics.
- Among the isolated compounds are the known phenazine antibiotics griseoluteic acid and griseolutein A, alongside two new phenazine derivatives and other known compounds.
- The paper details the structure identification of these new metabolites, their antibacterial properties, and proposes a theoretical pathway for how the new phenazine derivatives are formed.
Article Abstract
Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846220 | PMC |
| http://dx.doi.org/10.1021/np9005647 | DOI Listing |
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