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Asian variant intravascular large B-cell lymphoma with highly suspected central nervous system involvement: A case report.
World J Clin Cases
November 2023
Department of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, South Korea.
Article Synopsis
- The text discusses a rare type of lymphoma called intravascular large B-cell lymphoma (IVLBCL), particularly the Asian variant, which is associated with severe symptoms and bone marrow involvement, but less commonly affects the central nervous system (CNS).
- It presents a case study of a 67-year-old woman who experienced cognitive decline, fever, and bicytopenia, with imaging suggesting CNS issues despite no malignant cells in her cerebrospinal fluid; evidence of the disease was found in her bone marrow and through imaging and biopsy.
- The conclusion emphasizes that recognizing signs of IVLBCL and an accurate diagnosis are crucial for timely treatment, highlighting the importance of thorough CNS examination during diagnosis.
A Comprehensive Clinicopathologic and Molecular Study of 19 Primary Effusion Lymphomas in HIV-infected Patients.
Am J Surg Pathol
March 2022
Departments of Pathology.
Primary effusion lymphoma (PEL) is associated with human herpesvirus 8 and frequently with Epstein-Barr virus (EBV). We report here a single-center series of 19 human immunodeficiency virus-associated PELs, including 14 EBV+ and 5 EBV- PELs. The objectives were to describe the clinicopathologic features of PELs, with a focus on programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) expression, to search for genetic alterations by targeted deep sequencing analysis, and to compare the features between EBV+ and EBV- cases.
View Article and Find Full Text PDFLymphoid Neoplasms With Plasmablastic Differentiation: A Comprehensive Review and Diagnostic Approaches.
Adv Anat Pathol
March 2020
Department of Pathology, Chi-Mei Medical Center, Tainan.
Plasmablastic neoplasms encompass several entities including plasmablastic lymphoma, plasmablastic plasmacytoma/multiple myeloma, primary effusion lymphoma and its extracavitary variant, anaplastic lymphoma kinase-positive large B-cell lymphoma, and Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (HHV8)-positive diffuse large B-cell lymphoma, not otherwise specified. Morphologically, the tumor cells are large with eccentrically located nuclei, prominent nucleoli, and basophilic/amphophilic cytoplasm. Immunophenotypically, the tumor cells express plasma cell-related antigens including CD38, CD138, interferon regulatory factor-4 (IRF4)/MUM1, PR domain zinc finger protein-1 (PRDM1), and/or X-box binding protein-1 (XBP1), with frequent loss of CD20.
View Article and Find Full Text PDF[Prognostic Value of Morphology and Hans Classification in Diffuse Large B Cell Lymphoma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2018
Department of Hematology, Hangzhou First People's Hospital，Hangzhou 310006，Zhejiang Province，China.
Objective: To investigate the prognostic value of morphology and Hans classification in diffuse large B cell lymphoma（DLBCL）.
Methods: Clinical data of 249 patients diagnosed with DLBCL in our hospital and Hangzhou Xixi hospital during Jan 2006 to Dec 2016 were analyzed retrospectively. These patients were classified into 3 groups: immunoblastic variant（IB） group, centroblastic variant（CB） group and others group according to the cell morphology.
Indolent lymphomas in the pediatric population: follicular lymphoma, IRF4/MUM1+ lymphoma, nodal marginal zone lymphoma and chronic lymphocytic leukemia.
Virchows Arch
February 2016
Department of Pathology, Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Indolent lymphomas in the pediatric population were discussed during the 2014 European Association for Haematopathology/Society of Hematopathology workshop in Istanbul, Turkey. This session was focused on pediatric-type follicular lymphoma (FL), and its differential diagnosis with the newly recognized entity of IRF4/MUM1+ lymphomas mainly involving Waldeyer's ring. The differential diagnosis between t(14;18) negative FL grade 1/2 and pediatric-type FL in adults was highlighted.
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