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Barcoding Identifies Biclonal Mycobacterium ulcerans Buruli Ulcer, Côte d'Ivoire.
Microbiol Spectr
June 2023
IRD, MEPHI, IHU Méditerranée Infection, Aix-Marseille-Université, Marseille, France.
Mycobacterium ulcerans, an environmental opportunistic pathogen, causes necrotic cutaneous and subcutaneous lesions, named Buruli ulcers, in tropical countries. PCR-derived tests used to detect M. ulcerans in environmental and clinical samples do not allow one-shot detection, identification, and typing of M.
View Article and Find Full Text PDFA POLE Splice Site Deletion Detected in a Patient with Biclonal CLL and Prostate Cancer: A Case Report.
Int J Mol Sci
August 2021
Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (LIMCR), Cancer Cluster Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
Chronic lymphocytic leukemia (CLL) is considered a clonal B cell malignancy. Sporadically, CLL cases with multiple productive heavy and light-chain rearrangements were detected, thus leading to a bi- or oligoclonal CLL disease with leukemic cells originating either from different B cells or otherwise descending from secondary immunoglobulin rearrangement events. This suggests a potential role of clonal hematopoiesis or germline predisposition in these cases.
View Article and Find Full Text PDFSomatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges.
Front Cell Dev Biol
August 2021
St. Anna Children's Cancer Research Institute, Vienna, Austria.
Stable aneuploid genomes with nonrandom numerical changes in uneven ploidy ranges define distinct subsets of hematologic malignancies and solid tumors. The idea put forward herein suggests that they emerge from interactions between diploid mitotic and G0/G1 cells, which can in a single step produce all combinations of mono-, di-, tri-, tetra- and pentasomic paternal/maternal homologue configurations that define such genomes. A nanotube-mediated influx of interphase cell cytoplasm into mitotic cells would thus be responsible for the critical nondisjunction and segregation errors by physically impeding the proper formation of the cell division machinery, whereas only a complete cell fusion can simultaneously generate pentasomies, uniparental trisomies as well as biclonal hypo- and hyperdiploid cell populations.
View Article and Find Full Text PDFProgressive gammopathy and coagulopathy in a young English bulldog.
Can Vet J
February 2021
Tufts University, Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Grady, Kakar); Colorado State University, College of Veterinary Medicine and Biomedical Science, Department of Microbiology, Immunology, and Pathology, 200 West Lake Street, Fort Collins, Colorado 80523 USA (Avery, Moore, Harris, Rout).
A restricted polyclonal or biclonal gammopathy resulting in bleeding tendencies was diagnosed in a young, neutered male English bulldog with concurrent splenomegaly, anemia, and severe elevations in IgM and, to a lesser degree, IgA immunoglobulins. There was a positive clinical response to treatment with prednisone and chlorambucil. This case bears similarity to a recently published syndrome of polyclonal gammopathy that is not neoplastic in origin in this breed.
View Article and Find Full Text PDFProfiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer
October 2018
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Background: Clonal VDJ rearrangement of B/T cell receptors (B/TCRs) occurring during B/T lymphocyte development has been used as a marker to track the clonality of B/T cell populations.
Methods: We systematically profiled the B/T cell receptor repertoire of 936 cancer cell lines across a variety of cancer types as well as 462 Epstein-Barr Virus (EBV) transformed normal B lymphocyte lines using RNA sequencing data.
Results: Rearranged B/TCRs were readily detected in cell lines derived from lymphocytes, and subclonality or potential biclonality were found in a number of blood cancer cell lines.
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