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Unraveling the synthetic strategy, structure activity relationship of azetidinones: Insights into their multidrug and toxin extrusion protein (MATE transporter) inhibition facilitating drug development against MDR.
Bioorg Chem
January 2025
Medicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Campus-2, Ghatikia, Kalinga Nagar, Bhubaneswar, Odisha 751003, India. Electronic address:
Heterocyclic chemistry gathered a wide audience due to their presence in potential drug candidates and being attractive synthons initiating several retro-syntheses the organic as well as in medicinal chemistry fields. Among them, azetidinones have been a subject of discussion due to their serendipity, curiosity, versatility by Penicillin and Cephalosporins as β-lactam antibiotics. Despite possessing a large margin of biological activities, azetidinones mainly work as antimicrobial, interfering with bacterial cell-wall synthesis blocking transpeptidase.
View Article and Find Full Text PDFA clinical challenge: delayed diagnosis of autoimmune polyglandular syndrome type II in a patient with thyroid eye disease.
Orbit
January 2025
Department of Ophthalmology and Visual Sciences, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
A 35-year-old woman with thyroid eye disease (TED) was found to have autoimmune polyglandular syndrome type II (APS-II) 1 year after developing symptoms of this rare syndrome, during which she underwent 8 emergency department visits before receiving a targeted endocrinology workup. Thyroid disease is the second most common autoimmune syndrome associated with APS-II after primary adrenal insufficiency. Identification of this syndrome is critical as it can be life-threatening if left untreated.
View Article and Find Full Text PDFAge-related differences in eye blink-related neural activity and functional connectivity during driving.
Heliyon
January 2025
Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors, 44139, Dortmund, Germany.
Article Synopsis
- Driving involves complex coordination that deteriorates with age, affecting cognitive and motor functions.
- A study compared blink behavior and neural responses in younger and older adults during reactive and proactive driving tasks, revealing that younger participants had shorter blink durations and more efficient neural processing.
- Functional connectivity analysis indicated that younger adults exhibit stronger network integration in various brain areas, while older adults showed signs of compensatory mechanisms in attention networks, suggesting adaptability in response to cognitive demands.
Comparative analysis of ethical standards for the utilization of Assisted Reproductive Technologies in Brazil: Resolutions from 1992 to 2023.
JBRA Assist Reprod
December 2024
Christus University Center (Unichristus), Fortaleza, CE, Brazil.
Due to its documented records and technological achievements, in vitro embryo creation technology is still honored worldwide forty years after Louise Brown's birth on July 25, 1978. The World Health Organization (WHO) reports that one in six people globally who are of reproductive age may have infertility at some point in their lives. In this environment, it has become noteworthy for couples or patients to want to become pregnant through operations carried out by Assisted Human Reproduction Centers (AHRCs).
View Article and Find Full Text PDFDevelopment of Robust Lane-Keeping Algorithm Using Snow Tire Track Recognition in Snowfall Situations.
Sensors (Basel)
December 2024
Department of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
This study proposed a robust lane-keeping algorithm designed for snowy road conditions, utilizing a snow tire track detection model based on machine learning. The proposed algorithm is structured into two primary modules: a snow tire track detector and a lane center estimator. The snow tire track detector utilizes YOLOv5, trained on custom datasets generated from public videos captured on snowy roads.
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