Objective: To present the situation and burden of renal diseases and dialysis in the Republic of Macedonia in the period 1983-2007.
Methodology: A descriptive-statistical method has been applied with retrospective analysis of data for the period 1983-2007. Data from standard reports from ambulatory, dispensary and hospital services in the Republic of Macedonia, mortality statistics for the Republic of Macedonia, data from the World Health Organization and other professional literature and materials have been used.
Results And Discussion: Morbidity data from ambulatory and dispensary services in the period 1997-2007 show that renal diseases have increased by 64.7%, with rates rising from 319.5/10,000 population in 1997 to 514.5/10,000 in 2007. There has also been a rise in hospital health care for renal diseases, which is mainly due to the increase of chronic renal failure patients. Renal failure in-patient morbidity has increased from 3.5/10,000 in 1983 to 8.2/10,000 in 2006. Mortality from urinary system diseases in the period 1983-2007 also increased from 8.2/100,000 in 1983 to 14.0/100,000 in 2007. The vast majority of all mortality cases are due to renal failure. At the same time, chronic renal failure represents a significant economic burden to the society.
Conclusions And Recommendations: The treatment of urinary system diseases, and especially of chronic renal failure, requires costly diagnostic procedures and treatment and long-term rehabilitation and these cause negative economic effects, long-term absenteeism, disability and premature death. It is necessary to stress the measures for health protection and promotion, as well as all levels of prevention of renal diseases.
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Indian J Pediatr
January 2025
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Objectives: To evaluate the predictive ability of furosemide stress test (FST), serum and urine cystatin-C in identifying progressive acute kidney injury (AKI) and the need for kidney replacement therapy (KRT).
Methods: Children aged one month to 18 y admitted in the pediatric intensive care unit (PICU) with Kidney Diseases Improving Global Outcomes (KDIGO) stage-1/2 AKI were enrolled. FST and serum and urine cystatin-C levels were performed and analyzed.
Mol Biol Rep
January 2025
Pediatric Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background: Interleukin-1 receptor-associated kinase1 (IRAK1) plays a considerable role in the inflammatory signaling pathway. The current study aimed to identify any association between (rs1059703) single nucleotide polymorphism (SNP) and vulnerability to rheumatological diseases in the pediatric and adult Egyptian population.
Patients And Methods: The current study included four patient groups: adult Systemic lupus erythematosus (SLE), Rheumatoid arthritis (RA), juvenile systemic lupus erythematosus (JSLE), and juvenile idiopathic arthritis (JIA).
Arch Dermatol Res
January 2025
Blood Purification Center, Zhejiang Hospital, 1229 Gudun Road, Xihu District, Hangzhou, Zhejiang, 310030, China.
Uremic pruritus (UP) is a debilitating condition frequently associated with chronic kidney disease, severely impairing patients' quality of life and contributing to increased mortality. Recent studies have suggested that intravenous sodium thiosulfate (STS) may offer therapeutic relief for pruritus in patients undergoing hemodialysis. To assess its effectiveness, we conducted a systematic review and meta-analysis to explore the potential of intravenous STS in managing UP.
View Article and Find Full Text PDFZhongguo Dang Dai Er Ke Za Zhi
January 2025
Department of Pediatrics, Jinling Hospital, Medical School of Nanjing University, Nanjing 210000, China.
Objectives: To study the significance of serum 25-hydroxyvitamin D [25-(OH)D] level in the clinicopathological characteristics and prognosis of children with immunoglobulin A vasculitis nephritis (IgAVN).
Methods: A retrospective analysis was conducted on the clinical data of children with IgAVN who underwent renal biopsy at Suzhou Hospital Affiliated to Anhui Medical University and Jinling Hospital of the Medical School of Nanjing University from June 2015 to June 2020. Based on serum 25-(OH)D level, the patients were divided into a normal group and a lower group.
Zhongguo Dang Dai Er Ke Za Zhi
January 2025
Department of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, China.
Objectives: To investigate the clinical sub-phenotype (SP) of pediatric acute kidney injury (AKI) and their association with clinical outcomes.
Methods: General status and initial values of laboratory markers within 24 hours after admission to the pediatric intensive care unit (PICU) were recorded for children with AKI in the derivation cohort (=650) and the validation cohort (=177). In the derivation cohort, a least absolute shrinkage and selection operator (LASSO) regression analysis was used to identify death-related indicators, and a two-step cluster analysis was employed to obtain the clinical SP of AKI.
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