Objective: To evaluate the safety and immunogenicity of split influenza virus vaccine made in changchun institute of biological products.
Methods: Cluster samples were selected by random to carry out the single center, open clinical trial.
Results: After one dose injection, the rate of local reaction were 0.6%, and fever rate was 4.52%. The majority of the people with fever were mild fever. The HI Antibody positive rate of Influenza H1N1, H3N2, and B type were 94.98%, 87.1% and 88.1%; Geometric mean titer (GMT) of the three types antibody increased 104.79, 69.97 and 40.83 times respectively. The antibody protective rate were 100%, 99.7%, and 98.4% respectively. There were statistical difference on the HI antibody positive rate, times of GMT increased, and the antibody protective rate among the three types of influenza vaccine.
Conclusion: It is safety of split influenza virus vaccine for the people who are > or = 3-years-old, which made in changchun institute of biological products, and with good immunogenicity.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Immunogenicity and safety of live attenuated influenza vaccine in children aged 3-17 years in China.
Vaccine
February 2025
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China. Electronic address:
(1) Background: The administration of a live attenuated influenza vaccine (LAIV) has emerged as a viable option for preventing pediatric infections. The LAIV vaccine is available in China based on efficacy results. However, LAIV immunogenicity in children aged 3-17 years old in China has not yet to be studied and reported broadly.
View Article and Find Full Text PDFQuantitative Comparison and Clustering of Circular Dichroism Spectra Using a Symmetrized Weighted Spectral Difference.
AAPS J
December 2024
Global Bioprocess Development, Vaccine CMC Development & Supply, Sanofi, 1541 Avenue Marcel Merieux, Marcy-L' Etoile, 69280, France.
Spectroscopy (UV-visible, circular dichroism, infrared, Raman, fluorescence, etc.) is of fundamental importance to determine the structures of macromolecules and monitor their stability, especially for drug products, based on proteins or nucleic acids. In their 2014 article, Dinh et al.
View Article and Find Full Text PDFEstimating standard-dose and high-dose Fluzone vaccine efficacies for influenza A based on HAI titers.
J Infect Dis
December 2024
Department of Epidemiology & Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
Background: The high-dose (HD) Fluzone influenza vaccine is currently recommended for individuals 65 and older, since it was shown in past studies to improve antibody responses and vaccine efficacy (VE) compared to a standard-dose (SD) formulation. Since influenza vaccines are frequently reformulated, monitoring any potential changes in VE is crucial. Traditional efficacy trials can be costly and time-consuming.
View Article and Find Full Text PDFB-cell dynamics underlying poor response upon split-inactivated influenza virus vaccination.
Front Immunol
December 2024
Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, United States.
Article Synopsis
- The study examined how different immune responses, classified as persistent non-responders and responders, influence memory B-cell responses after Fluzone vaccination against H1N1.
- Persistent responders showed a significantly higher increase in specific B-cell populations compared to non-responders, who displayed a unique profile with increased transitional B-cells and IgM-expressing memory B-cells.
- The findings indicate a complex relationship between antibody titers and various memory B-cell types, suggesting that understanding these differences could enhance future vaccine development.
Assessing human B cell responses to influenza virus vaccines and adjuvants in a PBMC-derived in vitro culture system.
Vaccine
January 2025
Department of Medical Microbiology & Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:
Article Synopsis
- In vitro systems using human peripheral blood mononuclear cells (PBMCs) can effectively evaluate vaccine responses, particularly focusing on B cells alongside T cells and antigen-presenting cells.
- The study investigated how B cells in PBMCs respond to different influenza vaccine formulations (whole inactivated virus vs. split virus) and the impact of the adjuvant CpG ODN 2395 on immune responses.
- Findings revealed that WIV stimulated better B cell differentiation and higher antibody production compared to SIV, with the combination of WIV and CpG leading to the most significant immune responses, highlighting the potential of using PBMCs in early vaccine evaluations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!