Aim: To re-evaluate the theory that colonic diverticulosis is associated with relapse of Clostridium difficile associated disease (CDAD) in light of data suggesting increasing rates of CDAD infection and relapse.
Methods: Charts were reviewed for patients with recurrent CDAD who had also had a prior colonoscopy or flexible sigmoidoscopy. An age and gender matched control group was used to compare the prevalence of diverticulosis.
Results: Twenty-two patients met the study criteria, and the prevalence of diverticulosis in patients with CDAD relapse was 23% compared to 32% in age and sex matched controls (P = 0.44). A significant proportion of patients with CDAD relapse had co-morbidities associated with immune suppression.
Conclusion: Diverticulosis does not appear to be associated with CDAD relapse.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807955 | PMC |
| http://dx.doi.org/10.3748/wjg.v16.i3.345 | DOI Listing |
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