Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.200905773 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Labyrinthopeptin A2 disrupts raft domains.
Chem Phys Lipids
July 2023
Institute of Research, Development, and Innovation in Healthcare Biotechnology (IDiBE), Universidad "Miguel Hernández", E-03202 Elche, Alicante, Spain. Electronic address:
Labyrinthopeptins constitute a class of ribosomal synthesized peptides belonging to the type III family of lantibiotics. They exist in different variants and display broad antiviral activities as well as show antiallodynic activity. Although their mechanism of action is not understood, it has been described that Labyrinthopeptins interact with membrane phospholipids modulating its biophysical properties and point out to membrane destabilization as its main point of action.
View Article and Find Full Text PDFLarge Scale Production and Downstream Processing of Labyrinthopeptins from the Actinobacterium .
Bioengineering (Basel)
June 2018
Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH, Inhoffenstraße 7, 38124 Braunschweig, Germany.
A method was established for the production of 1.2-fold and 4.2-fold increased amounts of the antiviral and central nervous system-active lantipeptides, labyrinthopeptins A1 and A2, respectively, isolated from the actinobacterium , to enable production in gram scale.
View Article and Find Full Text PDFBioactive Peptide Natural Products as Lead Structures for Medicinal Use.
Acc Chem Res
July 2017
Technische Universität Berlin, Institut für Chemie, Fachgebiet Biologische Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.
The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived natural products have been isolated from bacteria and fungi. Hence, microorganisms play a pivotal role as sources for novel drugs with an emphasis on anti-infective agents.
View Article and Find Full Text PDFBacterial Labionin-Containing Peptides and Sactibiotics: Unusual Types of Antimicrobial Peptides with Potential Use in Clinical Settings (a Review).
Curr Top Med Chem
April 2017
Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, UFRJ, Rio de Janeiro, Brazil.
One of the biggest challenges faced presently by clinicians is the emergence of multidrug -resistant pathogens that can infect humans and animals. To control the infections caused by such pathogens the development of new drugs is required. Bacteria are a rich source of ribosomally -synthesized antimicrobial peptides known as bacteriocins, which are characterized by the presence of a self-defense immunity system.
View Article and Find Full Text PDFDissecting reactions of nonlinear precursor peptide processing of the class III lanthipeptide curvopeptin.
J Am Chem Soc
October 2014
Fakultät II-Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin, Germany.
Lanthipeptides are ribosomally synthesized peptides which undergo extensive post-translational modifications. In addition to novel structural features and bioactivities, the in vitro study on the biosynthesis of the class III lanthipeptide labyrinthopeptin revealed a unique C- to N-terminal directionality of biosynthetic processing. The recently described class III lanthipeptide curvopeptin allowed investigating the directionality aspect in much greater detail: Structural characterization of nine curvopeptin biosynthesis intermediates by high-resolution mass spectrometry combined with a deuterium-labeling approach enabled for the first time building a comprehensive biosynthesis model featuring all three post-translational modification reactions: phosphorylation, elimination, and cyclization.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!