AI Article Synopsis
- The growth of online software for genetic studies is increasing rapidly, offering significant advantages to researchers.
- However, caution is needed as certain programs may require adjustments for accurate results.
- A study testing two haplogroup prediction programs on 119 Argentine samples highlighted potential reliability issues, revealing a high chance of incorrectly assigning haplogroups based on the software's predictive quality metrics.
Article Abstract
The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known haplotypes and haplogroups from Argentine populations. Quantitative estimates of the predictive quality of both software systems were computed with the uncertainty coefficient; and sensitivity, specificity, positive, and negative likelihood ratios were also calculated to assert the reliability of both programs, showing high probabilities of assigning an incorrect haplogroup.
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| http://dx.doi.org/10.1007/s00414-009-0404-1 | DOI Listing |
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