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Acceptability of Self-administered Acupressure for Knee Osteoarthritis in Middle-aged and Older Adults: A Mixed-method Secondary Analysis.
Complement Ther Med
January 2025
The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR. Electronic address:
Objectives: To evaluate the acceptability of self-administered acupressure for Knee osteoarthritis (KOA) among middle-aged and older adults.
Methods: This is a mixed-method acceptability evaluation was embedded in a randomized controlled trial on self-administered acupressure for KOA. Participants received two 2-hour training sessions on self-administered acupressure and were instructed to practice twice daily for 12 weeks.
Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative.
Surg Endosc
August 2022
Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Backgrounds: COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital resources in the search for alternatives. However, these resources are often limited to the extent they offer resident-surgeon interaction like a joint surgical performance does.
View Article and Find Full Text PDFA forward genetic screen identifies modifiers of rocaglate responsiveness.
Sci Rep
September 2021
Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Rocaglates are a class of eukaryotic translation initiation inhibitors that are being explored as chemotherapeutic agents. They function by targeting eukaryotic initiation factor (eIF) 4A, an RNA helicase critical for recruitment of the 40S ribosome (and associated factors) to mRNA templates. Rocaglates perturb eIF4A activity by imparting a gain-of-function activity to eIF4A and mediating clamping to RNA.
View Article and Find Full Text PDFMyeloid-Derived Suppressor Cells Hamper Natural Killer Cell Activity in Cancer: Role of Peptidases.
Crit Rev Immunol
November 2021
University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Biology, Ljubljana, Slovenia; Jožef Stefan Institute, Department of Biotechnology, Ljubljana, Slovenia.
Natural killer (NK) cells represent critical effectors of anti-tumor immune responses due to their ability to target tumor cells that escape recognition by the adaptive arm of the immune system. NK cell efficacy depends on multiple factors, including their propensity to infiltrate tumors, to reach activation threshold, and to differentiate into mature cytotoxic cells. The tumor microenvironment counteracts protective immunity by delivering anti-inflammatory signals, which stimulate the development of myeloid-derived suppressor cells (MDSC).
View Article and Find Full Text PDFPresents a rejoinder to comments made by Oltmanns (see record 2013-45025-017) and Markon (see record 2013-45025-018) on the original article by Widiger (see record 2013-45025-016) regarding personality disorders in the DSM-5. Widiger comments that one of the texts he enjoys a great deal is Jerry Wiggins' Paradigms of Personality Assessment. Widiger notes that Wiggins presents within this book five fundamentally different theoretical models for personality assessment (e.
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