Aim: To describe the anatomy and topography of the laryngeal fat body and of the space it lies within.
Materials And Methods: The study is carried out on series of histological sections of head and neck blocks from six foetuses and three newborns. Three adult necks were dissected, a fourth one analysed through sagittal median section. CT-Scan and MRI imaging complete the description.
Results: The laryngeal fat body (LFB) lies within the pre-epiglottic (PE) space that stands in the median anterior part of the upper infrahyoid region, located just below the level of the hyoid bone. The walls of the PE space are: superior (base), anterior lateral right and left, posterior, inferior (apex). This space is divided into two compartments by a median septum. The LFB consists in a rather pure fat, structured in large polyhedral lobules. It shows no limiting capsule.
Discussion: Dissection-based description of the PE space made in literature matches ours conducted on series of histological sections. All authors agree on the fat content of the space but some of them find a capsule around the LFB that we did not observe on our histological sections. CT-Scan and MRI imaging are accurate for analysis of these structures and of similar efficiency. The study of the LFB should be considered regarding the one of other fat bodies in the human body.
Conclusion: Anatomical knowledge of the PE space and its content, the LFB, is important, as alteration of their morphology is the early witness of neighbouring carcinological extension.
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http://dx.doi.org/10.1016/j.morpho.2009.12.002 | DOI Listing |
Nutr J
October 2024
Department of Chemotherapy Oncology, Zhongshan City People's Hospital, No.2, Sun Wen East Road, Zhongshan, 528400, Guangdong, China.
Purpose: Low-fat dietary (LFD) pattern refers to a dietary structure with reduced fat intake. The aim was to investigate the association between LFD pattern and risk of head and neck cancer (HNC).
Methods: Data were derived from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.
Radiologie (Heidelb)
November 2024
Deutsches Krebsforschungszentrum, Abteilung Radiologie, Heidelberg, Deutschland.
Clinical Problem: Detection of manual strangulation, choking and hanging, as well as the intensity of these actions, helps to clarify the course of events, to enforce the state's right to prosecute and ultimately to protect against further attacks. However, this is complicated by the scarcity of externally visible findings.
Standard Procedure To Date: The forensic examination of the head and neck after strangulation is carried out by means of external inspection to detect injuries and congestion above the strangulation level.
Tissue Eng Part B Rev
September 2024
Department of Biomedical Engineering, McGill University, Montreal, Canada.
Human vocal folds (VFs), a pair of small, soft tissues in the larynx, have a layered mucosal structure with unique mechanical strength to support high-level tissue deformation by phonation. Severe pathological changes to VF have causes including surgery, trauma, age-related atrophy, and radiation, and lead to partial or complete communication loss and difficulty in breathing and swallowing. VF glottal insufficiency requires injectable VF biomaterials such as hyaluronan, calcium hydroxyapatite, and autologous fat to augment VF functions.
View Article and Find Full Text PDFSci Rep
May 2024
Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.
Quantitative imaging in life sciences has evolved into a powerful approach combining advanced microscopy acquisition and automated analysis of image data. The focus of the present study is on the imaging-based evaluation of the posterior cricoarytenoid muscle (PCA) influenced by long-term functional electrical stimulation (FES), which may assist the inspiration of patients with bilateral vocal fold paresis. To this end, muscle cross-sections of the PCA of sheep were examined by quantitative image analysis.
View Article and Find Full Text PDFGut Microbes
May 2024
CTM UMR1231, Université de Bourgogne, Dijon, France.
High-fat diets alter gut barrier integrity, leading to endotoxemia by impacting epithelial functions and inducing endoplasmic reticulum (ER) stress in intestinal secretory goblet cells. Indeed, ER stress, which is an important contributor to many chronic diseases such as obesity and obesity-related disorders, leads to altered synthesis and secretion of mucins that form the protective mucus barrier. In the present study, we investigated the relative contribution of omega-3 polyunsaturated fatty acid (PUFAs)-modified microbiota to alleviating alterations in intestinal mucus layer thickness and preserving gut barrier integrity.
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