AI Article Synopsis
- The study aimed to explore the expression of Maspin in patients with oral squamous cell carcinoma and its connection to clinical features.
- Maspin levels were found to be significantly lower in cancerous tissues compared to non-malignant oral tissues, with significant associations between Maspin expression, lymph node metastasis, and patient survival rates.
- The findings suggest that Maspin could serve as a promising prognostic marker for patients with oral squamous cell carcinoma.
Article Abstract
Objective: To investigate the expression of mammary serine proteinase inhibitor(Maspin) in patients with oral squamous cell carcinoma and its relationship with clinicopathological features.
Methods: The Maspin protein expression was examined in 45 patients with oral squamous cell carcinoma and in non-malignant oral epithelia by immunohistochemical staining. The relationship between the Maspin protein expression and the clinicopathological parameters was statistically analyzed.
Results: The Maspin protein expression in the cancerous tissues of oral squamous cell carcinoma was lower than that in the non-malignant oral epithelia (P = 0.001). Negative correlation was found between the Maspin protein expression in cancerous tissue and the status of lymph node metastasis (P = 0.038). Positive Maspin protein expression indicated negative lymph node metastasis, and negative correlation was also found between the Maspin protein expression and the postoperative metastasis (P = 0.004). Positive correlation was found between the Maspin expression and the patients' survival rate (P = 0.014), patients with positive Maspin protein expression having higher survival rate than those with negative Maspin expression.
Conclusions: Maspin might be useful as a potential prognostic marker for oral squamous cell carcinoma.
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