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[Inhibitory role of SirT7 in the growth of P19 cell line]. | LitMetric

[Inhibitory role of SirT7 in the growth of P19 cell line].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao

National Laboratory of Medical Molecular Biology, Institute of National Laboratory of Medical Molecular Biology, Beijing 100005, China.

Published: December 2009

Objective: To study the regulatory role of SirT7, one of class histone deacetylases, on the proliferation of mouse embryonal carcinoma cell line P19.

Methods: We used an expression plasmid of SirT7 (151-402 amino acid residues) and its vector respectively to establish a stably expressed SirT7 and its control P19 cell lines. Recombinant DNA techniques, Western blot, cell growth curve, and flow cytometry were used in this paper.

Results: Compared with the control cells, the P19 cells had significantly lower growth rate in stably expressed SirT7. G1 to S cell cycle arrests were only seen in the SirT7 over-expressed cell line.

Conclusion: SirT7 play a dominant role in the grow inhibition of the P19 cells.

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Source
http://dx.doi.org/10.3881/j.issn.1000-503X.2009.06.014DOI Listing

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