Here we report the design of a new external electric field-controlled release system using functional dipolar molecules as nanoimpellers. The dipolar molecule 4-(3-cyanophenyl)butylene, which can reorient in response to external electric fields with different frequencies because of its strong inherent dipole moment, was synthesized and grafted onto the inner surfaces of mesopores. Under an alternating electric field, the swinging flexible molecular chains consequently push guest molecules out of the pore voids. This innovative approach to controlled release may provide important application opportunities in tumor treatment with a number of advantages in terms of local release with targetability, external remote control, and the nonelectrochemical nature of the process.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja907560y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aprotic electrolytes beyond organic carbonates: transport properties of LiTFSI solutions in sulphur based solvents.
ChemSusChem
December 2024
University of Rome La Sapienza, Department of Chemistry, P.le A. Moro 5, 00185, Rome, ITALY.
This work illustrates a physico-chemical study of the structural, dynamic, and transport properties of electrolytes made of LiTFSI solutions in sulphoxide and sulphone solvent mixtures. Experimental measurements, by Raman and NMR spectroscopies, as well as electrochemical impedance spectroscopy, reveal the formation of a variety of ionic aggregates depending on the solvent composition that significantly affect the ion mobility and conductivity of the electrolyte. Mixtures containing tetrahydrothiophene-1-oxide exhibit a larger ion mobility due to a rapid exchange mechanism between solvent molecules, whereas the use of tetramethylene sulphone favors the formation of ionic aggregates due to the strong dipolar interactions between solvent molecules.
View Article and Find Full Text PDFTrifluoroacetic Acid as a Molecular Probe for the Dense Phase in Liquid-Liquid Phase-Separating Peptide Systems.
Anal Chem
December 2024
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore.
Although trifluoroacetic acid (TFA) is not typically considered a Hofmeister reagent, it has been demonstrated to modulate biocoacervation. We show that TFA can be employed to probe specific interactions in coacervating bioinspired peptide phenylalanine (Phe) F-labeled at a single site, altering its liquid-liquid phase separation (LLPS) behavior. Solid-state nuclear magnetic resonance (NMR) spectroscopy revealed two dynamically distinct binding modes of TFA with Phe, resulting in a structured, dipolar-ordered complex and a more dynamic complex, highlighting the proximity between TFA and Phe.
View Article and Find Full Text PDFPaired correlations of dipolar liquid crystals: A mean-force-potentials approach.
Phys Rev E
November 2024
Institute for Problems in Mechanical Engineering of the Russian Academy of Science (IPME RAS), Bolshoy pr. V.O., 61, 199178 St-Petersburg, Russia.
Pair correlations for a polar liquid-crystal (LC) system have been theoretically investigated by means of integral equation approach. Using the dipolar Gay-Berne (GB) interactions between the molecules that composed the LC system, calculations of the nearest-neighbor (NN) and next-NN (NNN) correlators as well as the order parameters and the static dielectric coefficients were performed. It is shown that for a simple cubic packing, NN dipoles tend to be mutually antiparallel with respect to the central dipole, while the opposite trend was observed for NNN dipoles.
View Article and Find Full Text PDFLocalized discrete and asymmetric dark-bright soliton-like modes as nonlinear dynamics in microtubules.
Heliyon
November 2024
Laboratory of Research on Advanced Materials and Nonlinear Sciences, Department of Physics, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.
In the present work, we focus on the longitudinal model of microtubules (MTs) proposed by Satarić et al. (1993) [12], and that considers MT cells to have ferroelectric properties (behaviors) due to dipolar oscillations of dimers within MTs, i.e.
View Article and Find Full Text PDFComputational investigation of the dynamics of the constituents in a glucose-based biodegradable deep eutectic solvent.
J Chem Phys
December 2024
Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, 64287 Darmstadt, Germany.
Atomistically detailed force field is employed to investigate the dynamics of a naturally abundant deep eutectic solvent at 328 K, composed of glucose, urea, and water in a 6:4:1 mass ratio. This study examines key dynamical processes, including translational motion, molecular reorientation, and hydrogen bond relaxation, with timescales ranging from a few picoseconds to a few nanoseconds. Characteristic times associated with the translational and the rotational motion increase with molecular size, i.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!