A new triterpenic glucoside, lup-1,5,20(29)-trien-3-O-beta-D-glucopyranoside (4), along with three known phytoconstituents: n-octacosane, friedelin and beta-amyrin, has been isolated from the leaves of Clerodendrum inerme (L.) Gaertn. (Verbenaceae). Structure elucidation was carried out on the basis of chemical and physical evidence (IR, 1H-NMR, 13C-NMR, DEPT and MS spectra). The alcoholic and aqueous extracts of the leaves of C. inerme showed significant antinociceptive activity in analgaesiometer tests.
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http://dx.doi.org/10.1080/14786410902975566 | DOI Listing |
J Am Chem Soc
January 2025
Division of Biochemistry, Institute for Chemical Research (ICR), Kyoto University, Uji, Kyoto 611-0011, Japan.
Despite the unprecedented therapeutic potential of immune checkpoint antibody therapies, their efficacy is limited partly by the dysfunction of T cells within the cancer microenvironment. Combination therapies with small molecules have also been explored, but their clinical implementation has been met with significant challenges. To search for antitumor immunity activators, the present study developed a cell-based system that emulates cancer-attenuated T cells.
View Article and Find Full Text PDFInt J Med Sci
January 2025
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan.
Excessive exercise can lead to fatigue, consequently affect exercise performance, and further have an adverse impact to human health. The synergistic effects of ginsenosides, salidroside, and syringin on improving exercise performance remain unknown. Hence, the effects of Chinese herb powder (CHP) which consisted of bioactive compounds such as ginsenosides (Rg1, Re, and Rb1), salidroside, and syringin on exercise performance, energy metabolism, tissue damage, antioxidant activity, and inflammatory cytokine were investigated in exhaustive exercise rats.
View Article and Find Full Text PDFPlants (Basel)
November 2024
Department of Pharmacognosy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
L., also known as licorice, belongs to the family and is one of the most commercially valuable plants worldwide, being used in the pharmaceutical, cosmetic, and food industries, both for its therapeutic benefits as well as for the sweetening properties of the extract. This study evaluates the phytochemical composition, the biological activities, and the safety profile of a methanolic extract of licorice root (LRE) obtained from Romania.
View Article and Find Full Text PDFCarbohydr Polym
February 2025
College of Biosystems Engineering and Food Science, Key Laboratory for Quality Evaluation and Health Benefit of Agro-Products of Ministry of Agriculture and Rural Affairs, Key Laboratory for Quality and Safety Risk Assessment of Agro-Products Storage and Preservation of Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, China. Electronic address:
Phytomedicine
December 2024
State Key Laboratory of Oral Diseases & National Center of Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address:
Background: Oral lichen planus (OLP) is a common chronic inflammatory disease with the potential of malignant transformation. Hydroxychloroquine (HCQ), derived from quinine originating from Cinchona spp. bark, is a commonly prescribed off-label for OLP.
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