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http://dx.doi.org/10.1007/s00277-009-0891-7 | DOI Listing |
Enferm Infecc Microbiol Clin (Engl Ed)
December 2024
Servicio de Enfermedades Infecciosas, Consorci Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain.
Ther Drug Monit
December 2024
Université Jean Monnet, Médecine Intensive Réanimation G, CHU Saint-Etienne, INSERM, Mines Saint Etienne, Saint-Étienne, France.
Low-dose methotrexate has been proposed as therapy for patients with severely disabling psoriasis and psoriatic arthritis. However, it can be associated with severe toxicity, such as pancytopenia, characterized by anemia (hemoglobin level <13 g/dL in men), thrombocytopenia (platelet count <150 × 109/L), and neutropenia or agranulocytosis (neutrophil count <1.5 × 109/L and 0.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China.
Background: Sulfasalazine (SSZ) is commonly prescribed for the treatment of ulcerative colitis, rheumatoid arthritis, and ankylosing spondylitis. However, it can also trigger a severe drug reaction known as Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) or Drug-Induced Hypersensitivity Syndrome (DIHS). This article aims to analyze the clinical characteristics of DRESS/DIHS induced by SSZ and provide evidence for clinical diagnosis, treatment, and prevention.
View Article and Find Full Text PDFCureus
November 2024
Department of Neurological Surgery, Nagoya University Hospital, Nagoya, JPN.
Vertebral fractures (VFs) occasionally appear as the first manifestation of acute lymphocytic leukemia (ALL) in children. However, in adults, it is uncommon for VFs to lead to a diagnosis of ALL, and surgical intervention is even rarer. We encountered a case of a 42-year-old man with ALL who presented with acute severe back pain, lower limb numbness, dysuria, and hamstring weakness.
View Article and Find Full Text PDFCureus
November 2024
Research Unit, Hospital San Juan de Dios, Costa Rican Social Security Health Fund (CCSS), San José, CRI.
Background Aplastic anemia (AA) is a rare and heterogeneous hematological disorder defined as pancytopenia with hypocellular bone marrow in the absence of abnormal infiltration or medullary fibrosis. Various causes of AA have been identified, such as autoimmune factors, bone marrow injuries, viral infections, and genetic disorders. The symptoms of AA are directly linked to pancytopenia and the most common are fatigue, recurrent infections, and bleeding problems.
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