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Background And Objective: Given the uncertainty regarding the role of radical nephroureterectomy (RNU) as part of a multimodal treatment strategy for upper tract urothelial carcinoma (UTUC) patients with cN+ disease, we aimed to perform a systematic review and meta-analysis of the corresponding literature.

Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, we identified 17 observational comparative and noncomparative studies, published between January 2000 and September 2024, evaluating UTUC patients with cTanyN+M0 disease (P) who received RNU as part of a multimodal treatment strategy (I), as compared with any treatment strategy if applicable (C), to assess oncological or postoperative outcomes (O). Meta-analyses were further performed, as appropriate.

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  • The study tested if disseminated intravascular coagulation (DIC) is linked to worse outcomes in patients who had out-of-hospital cardiac arrest (OHCA) and received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment.
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  • Results showed that patients with DIC had significantly higher in-hospital mortality, and DIC scores measured after 24 hours proved to be a moderate predictor of death in these patients.
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