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| http://dx.doi.org/10.1371/journal.pbio.0040391 | DOI Listing |
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Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.
J Exp Biol
January 2025
Department of Biology, Aarhus University, DK-8000 Aarhus C, Denmark.
The ability of organisms to cope with poor quality nutrition is essential for their persistence. For species with a short generation time, the nutritional environments can transcend generations, making it beneficial for adults to prime their offspring to particular diets. However, our understanding of adaptive generational responses, including those to diet quality, are still very limited.
View Article and Find Full Text PDFUndernutrition-induced stunting-like phenotype in .
Narra J
December 2024
Department of Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Stunting resulting from undernutrition is a significant global health challenge, particularly in developing countries, yet its underlying mechanisms and consequences remain inadequately understood. This study utilizes as an in vivo model to investigate the molecular basis of stunting. Due to the conserved nature of signaling pathways between and vertebrates, this organism serves as an effective model for studying growth disorders.
View Article and Find Full Text PDFPhotoperiodic plasticity of pigment-dispersing factor immunoreactive fibers projecting toward prothoracicotropic hormone neurons in flesh fly Sarcophaga similis larvae.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol
January 2025
Graduate School of Science, The University of Osaka, 1-1 Machikaneyama-cho, Toyonaka, Osaka, 560-0043, Japan.
Larvae of the flesh fly, Sarcophaga similis exhibit photoperiodic responses to control pupal diapause. Although the external coincidence model is applicable to S. similis photoperiodism, it remains unknown how the circadian clock system integrates day-length information.
View Article and Find Full Text PDFEpoxide hydrolases JHEH1 and JHEH2 deficiency impairs glucose metabolism in Drosophila.
Biochem Biophys Res Commun
January 2025
Department of Biological Sciences, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan. Electronic address:
Epoxide hydrolases (EHs) play pivotal roles in detoxification, catabolism, and signaling by converting epoxides into diols and have been implicated in several diseases, such as cancers and diabetes. EH homologs in insects are designated as Juvenile hormone epoxide hydrolases (JHEHs) due to their catalytic activity toward Juvenile hormone (JH). However, the biological function of JHEHs has been controversial in the fruit fly Drosophila melanogaster.
View Article and Find Full Text PDFNew Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia.
ASN Neuro
January 2025
School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect the mechanism, we present evidence here that lack of glial dAux enhanced the phosphorylation of the autophagy-related protein Atg9 at two newly identified threonine residues, T62 and T69. The enhanced Atg9 phosphorylation in the absence of dAux promotes autophagosome formation and Atg9 trafficking to the autophagosomes in glia.
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