AI Article Synopsis
- - The study investigated the risk of erosive esophagitis (EE) and gastroduodenal mucosal injury in Japanese patients taking low-dose aspirin (ASA), comparing them to a control group not on aspirin.
- - Out of 159 ASA users, the prevalence of EE was found to be 9.4%, which was similar to the 6.3% in the non-aspirin control group, while peptic ulcers were more common in the ASA group at 14% compared to 4% in controls.
- - The conclusion suggests that for Japanese patients on low-dose ASA, EE is less prevalent than peptic ulcers, indicating a need for further research on the gastrointestinal effects of aspirin.
Article Abstract
Background And Aim: The risk for erosive esophagitis (EE) with low-dose aspirin (ASA) remains unknown, especially among Japanese patients. We conducted the present study to compare the risk of EE with that of gastroduodenal mucosal injury among Japanese patients taking ASA.
Methods: From 5555 patients undergoing upper gastrointestinal endoscopy from January 2005 to December 2006 at Teikyo University Hospital, Tokyo, Japan, 159 patients (76 males and 83 females, mean age: 69.3 +/- 11 years) fulfilling the following conditions were selected: (i) taking ASA (less than 100 mg/day) continuously; (ii) not taking acid suppressants; and (iii) no history of gastrointestinal tract surgery, malignancies, severe cardiac failure, or liver cirrhosis. Age- and sex-matched patients not taking aspirin were randomly chosen as controls (n = 159). Two well-experienced endoscopic examiners evaluated endoscopic records to determine the presence or absence of esophageal hiatal hernia, EE, and gastroduodenal ulcers.
Results: The prevalence of EE in patients taking aspirin (9.4%) was not different from that of the controls (6.3%, odds ratio [OR]: 1.5, 95% confidence interval [CI]: 0.7-3.2), whereas peptic ulcers were found more frequently in the aspirin group (14%) than in the control group (4%, OR: 3.6, 95% CI: 1.5-8.8).
Conclusion: In Japanese patients taking ASA, EE was not as common as peptic ulcers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1440-1746.2009.06105.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!