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Mixed-methods reproductive health knowledge, attitudes and practices survey of IDPs, returnees and host communities in Jonglei State, South Sudan.
BMJ Open
January 2025
IMA World Health, Kinshasa, Democratic Republic of the Congo.
Objectives: To understand the current state of maternal, newborn and child health (MNCH) among internally displaced persons (IDPs), returnees and host communities in remote counties of Jonglei state.
Design: Cross-sectional, randomly sampled, mixed-methods, population-based household study.
Setting: Ayod, Nyirol, Fangak and Pigi counties of Jonglei, South Sudan.
Ofatumumab-exposed breastfeeding in multiple sclerosis patients.
Mult Scler
January 2025
Department of Neurology, St. Josef-Hospital, Katholisches Klinikum Bochum, Ruhr-University Bochum, Bochum, Germany.
Background: In Europe, ofatumumab is approved for breastfeeding, but data on its transfer into breast milk and clinical experience are lacking.
Objective: To analyze (1) health, development, and adverse events after live vaccination of ofatumumab-exposed breastfed infants and (2) detectability of ofatumumab in breast milk, and to calculate the relative infant dose (RID) using two methods, the traditional method and a second method considering maternal exposure to multiple ofatumumab doses and extended collection period.
Methods: In this observational study, clinical data were collected by standardized telephone interviews up to 2 years postpartum.
Pregnancy and Infant Outcomes in Women With Multiple Sclerosis Treated With Ocrelizumab.
Neurol Neuroimmunol Neuroinflamm
January 2025
Katholisches Klinikum Bochum, St. Josef Hospital, Bochum, Germany.
Background And Objectives: Ocrelizumab labeling advises contraception for women during treatment and for 6-12 months thereafter. Because pregnancies may occur during this time, it is critical to understand pregnancy and infant outcomes in women with multiple sclerosis (MS) after ocrelizumab exposure.
Methods: Pregnancy cases reported to Roche global pharmacovigilance until 12 July 2023 were analyzed.
Article Synopsis
- The World Health Assembly set six global nutrition targets (GNTs) in 2012 to improve maternal and child health, but there has been no comprehensive report detailing progress from 2012 to 2021.
- A study evaluated the prevalence and impact of these nutrition targets across 204 countries using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 and projected future trends up to 2050.
- By 2021, only a few countries met some GNTs; most showed increased child overweight and notable decreases in female anaemia, highlighting a connection between societal development status and nutritional challenges.
Microbiological analysis of donor human milk over seven years from the Hearts Milk Bank (United Kingdom).
Food Microbiol
March 2025
School of Biological Sciences and Institute for Global Food Security, Queen's University Belfast, UK. Electronic address:
When maternal milk is unavailable, donor human milk (DHM) from human milk banks (HMBs) is the optimal alternative, as recommended by the World Health Organisation. The microbiota of DHM could contain opportunistic pathogens, which means rigorous microbiological screening for DHM, prior to pasteurisation, is recommended to safeguard recipients. Here, an analysis of 6863 DHM samples from 1419 donors at the Hearts Milk Bank between 2017 and 2023 showed approximately 70.
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