Dysregulation of the UPS (ubiquitin-proteasome system) has been implicated in a wide range of pathologies including cancer, neurodegeneration and viral infection. Inhibiting the proteasome has been shown to be an effective therapeutic strategy in humans; however, toxicity with this target remains high. E3s (Ub-protein ligases) represent an alternative attractive therapeutic target in the UPS. In this paper, we will discuss current platforms that report on E3 ligase activity and can detect E3 inhibitors, and underline the advantages and disadvantages of each approach.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060714 | PMC |
| http://dx.doi.org/10.1042/BST0380132 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dense stroma activates the TGF-β1/FBW7 axis to induce metabolic subtype switching in pancreatic cancer.
Int J Surg
January 2025
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases. Although several chemotherapy regimens have been developed over the past decades, few targeted therapies have shown a significant improvement in overall survival, partly due to the identification of PDAC as a single disease.
Methods: Combining metabolomic analysis and immunohistochemistry staining with Oil Red O staining, analysis for the oxygen consumption rate and extracellular acidification rate, we stratified pancreatic cancer cells into two subtypes.
Isolation and Identification of Apiospora intestini from Hedera nepalensis Leaf Blight and Determination of Antagonism of Phomopsis sp.
Curr Microbiol
January 2025
College of Landscape Architecture and Horticulture Sciences, Southwest Forestry University, Kunming, 650224, China.
In order to identify the pathogen responsible for Hedera nepalensis leaf blight and investigate effective biocontrol strategies, samples were collected from 10 significantly infected areas at Southwest Forestry University; four to six infected leaves were gathered from each area, followed by the isolation and purification of strains from the infected plant leaves using tissue isolation and hyphae-purification techniques. We conducted an examination of the biological characteristics and compared the inhibitory effects of different concentrations of Phomopsis sp. (50%, 25%, 16.
View Article and Find Full Text PDFPCR-based detection technique and gamma irradiation strategies for managing -induced brown rot of potato.
Int J Radiat Biol
January 2025
Department of Horticulture, Patuakhali Science and Technology University, Patuakhali, Bangladesh.
Purpose: The study focused on developing a rapid PCR-based detection method and employing gamma irradiation techniques to manage , aiming to produce brown rot-free export-quality potatoes. This initiative seeks to enhance potato exports from Bangladesh.
Materials And Methods: Samples of potato tubers and soil were collected from various commercially significant potato-growing areas, resulting in a total of 168 isolates from potato tubers and soil across 12 regions.
Identification and Validation of a m6A-Related Long Noncoding RNA Prognostic Model in Colorectal Cancer.
J Cell Mol Med
January 2025
Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Accumulating research indicates that N6-methyladenosine (m6A) modification plays a pivotal role in colorectal cancer (CRC). Hence, investigating the m6A-related long noncoding RNAs (lncRNAs) significantly improves therapeutic strategies and prognostic assessments. This study aimed to develop and validate a prognostic model based on m6A-related lncRNAs to improve the prediction of clinical outcomes and identify potential immunological mechanisms in CRC.
View Article and Find Full Text PDFElectrocatalytic reduction of CO to produce the C products: from selectivity to rational catalyst design.
Nanoscale
January 2025
College of Energy Source and Mechanical Engineering, Shanghai University of Electric Power, Shanghai 200090, People's Republic of China.
Electrocatalytic reduction of CO (eCORR) into valuable multi-carbon (C) products is an effective strategy for combating climate change and mitigating energy crises. The high-energy density and diverse applications of C products have attracted considerable interest. However, the complexity of the reaction pathways and the high energy barriers to C-C coupling lead to lower selectivity and faradaic efficiency for C products than for C products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!