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Microenvironment Remodeling Microgel Repairs Degenerated Intervertebral Disc via Programmed Delivery of MicroRNA-155.
ACS Appl Mater Interfaces
January 2025
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
The progression of intervertebral disc degeneration (IVDD) is associated with increased cell apoptosis and reduced extracellular matrix (ECM) production, both of which are driven by ongoing inflammation. Thus, alleviating the acidic inflammatory microenvironment and mitigating the apoptosis of nucleus pulposus cells (NPCs) are essential for intervertebral disc (IVD) regeneration. Regulating pH levels in the local environment can reduce inflammation and promote tissue recovery.
View Article and Find Full Text PDFPenile Reconstruction in Aphallia: Modification of the De Castro Technique With Large Tissue Expander.
Plast Reconstr Surg Glob Open
January 2025
From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT.
Aphallia is an exceedingly rare congenital malformation. The condition is the result of a sporadic anatomic anomaly during fetal development in a 46, XY male patient with otherwise normal functioning testes and male sexual hormone metabolism. Neophallus reconstruction using the De Castro phalloplasty technique is currently the most accepted treatment modality for this condition.
View Article and Find Full Text PDFComplex Ureteral Reconstruction via Open or Robotic Ureteroplasty with a Buccal Mucosa Onlay Graft: A Two-center Comparison.
Eur Urol Open Sci
January 2025
Department of Urology, St. Josef Medical Center, University of Regensburg, Regensburg, Germany.
Background And Objective: Management of a long proximal ureteral stricture is challenging. Buccal mucosal graft (BMG) ureteroplasty is a reliable technique for ureteral reconstruction that avoids the morbidity of bowel interposition or autotransplantation. We compared open and robotic BMG ureteroplasty in a two-center study.
View Article and Find Full Text PDFSurgical and patient-reported outcomes of staged urethroplasty for anterior urethral strictures: A comprehensive analysis.
Int J Urol
January 2025
Department of Urology, National Defense Medical College, Saitama, Japan.
Objectives: To evaluate the efficacy of staged urethroplasty for complex anterior urethral strictures from both surgical and patient-reported outcome perspectives.
Methods: This retrospective study included 100 patients who underwent staged urethroplasty for anterior urethral strictures between May 2011 and June 2023. Anatomical success was defined as the ability to pass cystourethroscopy without resistance and the patient's ability to void without additional interventions.
Surgical outcomes of artificial urinary sphincter implantation in patients with a history of urethroplasty: A retrospective analysis.
Int J Urol
January 2025
Department of Urology, National Defense Medical College, Saitama, Japan.
Objectives: Limited data exist on surgical outcomes following artificial urinary sphincter (AUS) implantation in patients with a history of urethroplasty for urethral stricture. This study aimed to evaluate the surgical outcomes of AUS implantation in such patients, focusing on the risk of urethral erosion.
Methods: We retrospectively reviewed 14 male patients who developed severe urinary incontinence following urethroplasty for urethral stricture and subsequently underwent AUS implantation at our center between March 2012 and January 2024.
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