Objectives: To evaluate the incidence and pattern of hearing loss in non-explosive blast injury of the ear.
Study Design: Prospective clinical study.
Setting: Tertiary referral centre.
Participants: Consecutive patients who suffered physical blow to the ear resulting in tympanic membrane perforations without history of previous middle ear disease.
Main Outcome Measures: Incidence of conductive and sensorineural hearing loss, extent of air-bone gap versus size and site of perforation, post-healing hearing loss recovery.
Results: Fifty-one patients, 31 males (61%) and 20 females (39%) aged 10-56 years, were recruited over a 30 month study period. The prevalence of hearing loss was significantly more in the injured ears than contralateral normal ears (chi(2) = 76.26; P = 0.000). Pure conductive hearing loss occurred in 39%, while 28% (14 patients) had mixed hearing loss. Three patterns of sensorineural loss were observed: dip involving several adjacent high frequencies, a dip in a single frequency, and two separate dips involving low and high frequencies. The extent of air-bone gap correlated with the size of perforation (r = 0.33; P = 0.01). Ears that sustained small tympanic membrane perforation showed significantly small average air-bone gap (t = 2.97; P = 0.005). The mean air-bone gap difference between the anterior and posterior perforations was not significant (t = 1.7; P = 0.09). Closure of air bone gap following healing was significant (t = 15.08; P < 0.01), while recovery of bone conduction abnormality was less favourable.
Conclusion: Conductive hearing loss occurring in the speech frequencies was the most common form of hearing loss in this group of patients with non-explosive blast injury to the ear. The accompanying sensorineural loss mostly affected several adjacent high frequencies. Healing of perforation favoured significant recovery of the conductive loss, but recovery of sensorineural loss was less favourable.
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http://dx.doi.org/10.1111/j.1749-4486.2009.02035.x | DOI Listing |
Hum Genet
January 2025
Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-Ku, Tokyo, 152-8902, Japan.
There are hundreds of rare syndromic diseases involving hearing loss, many of which are not targeted for clinical genetic testing. We systematically explored the genetic causes of undiagnosed syndromic hearing loss using a combination of whole exome sequencing (WES) and a phenotype similarity search system called PubCaseFinder. Fifty-five families with syndromic hearing loss of unknown cause were analyzed using WES after prescreening of several deafness genes depending on patient clinical features.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Tianjin Medical University, Tianjin, 300102, China.
Objective: This study aims to investigate the genetic link between psoriasis and sudden sensorineural hearing loss (SSNHL).
Methods: From a genetic standpoint, this study further highlighted the connection between psoriasis and SSNHL. Single nucleotide polymorphisms (SNPs) connected to SSNHL could be found using a genome-wide association study from the IEU OpenGWAS project website.
BMC Neurol
January 2025
Faculty of Medicine, Department of Neurology, Al-Quds University, Jerusalem, Palestine.
Background: Vanishing white matter disease (VWMD) is a rare autosomal recessive leukoencephalopathy. It is typified by a gradual loss of white matter in the brain and spinal cord, which results in impairments in vision and hearing, cerebellar ataxia, muscular weakness, stiffness, seizures, and dysarthria cogitative decline. Many reports involve minors.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Audiovestibular Medicine, St George's Hospital, London, UK.
A toddler presented to audiovestibular medicine with mild bilateral, sensorineural hearing loss identified via the Newborn Hearing Screening Programme. This report focuses on the early clinical assessment and aetiological investigation which prompted testing for metabolic disease and highlights the parents' perspective. Early investigation led to a relatively early diagnosis of mucopolysaccharidosis (MPS) type IIIA: Sanfilippo disease which enabled the family to access a novel treatment option which otherwise would not have been possible.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Haematology, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
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