AI Article Synopsis
- Diabetes mellitus significantly affects the oral cavity, leading to various conditions such as candidiasis, gingivitis, and potential links to oral cancer.
- A case study of a young woman with type 1 diabetes revealed a hyperplastic oral mucosa lesion with p53 expression, indicating possible cancer risk.
- Managing this patient's condition required a multidisciplinary approach and ongoing clinical monitoring.
Article Abstract
Diabetes mellitus is one of the chronic systemic disorders with major influences of the oral cavity microenvironment. Oral manifestations of diabetes are diverse; they are represented by candidose, lichen plan, recurrent aphthous stomatitis, gingivitis, salivary disorders, oral mucosa atrophy and rarely hypertrophy; a possible link between oral cancer and diabetes is suspected, both in animal models and humans. We report a case of a young woman with type 1 diabetes with class I Kennedy edentation with mobile denture prosthesis; latter in the clinical follow-up, a hyperplasic lesion of the oral mucosa with p53 expression within the epithelial nuclei was identified, p53 being the more likely pathogenic pathway involved in diabetes-related oral cancer. The approach of this patient required multidisciplinary investigations and careful follow-up.
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