Objective: To evaluate the impact of ARLTS1 gene mutations among Chinese Han-nationality patients with early-onset epithelial ovarian carcinoma (OC) in Southern China.
Methods: Tumor and blood samples collected from early-onset, late-onset epithelial ovarian carcinoma patients and control group were collected. After purification of DNA, the ARLTS1 gene fragments were amplified with PCR. The DHPLC was applied to analyze the PCR products. The mutation products were confirmed with DNA sequencing analysis.
Results: ARLTS1 Cys148Arg revealed a significant association with an increased risk in early-onset OC group compared with both late-onset cases and controls. ARLTS1 Ser99Ser revealed no impact on both early-onset OC group and late-onset cases.
Conclusion: A significantly increased risk for young ovarian cancer patients with ARLTS1 Cys148Arg variant were observed, which indicate that ARLTS1 may play a important role in early-onset of OC.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling.
J Biol Chem
June 2018
From the Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India
DP-ibosylation factor-ike GTPase () is a cancer-predisposing gene that has remained functionally uncharacterized to date. In this study, we report that ARL11 is endogenously expressed in mouse and human macrophages and regulates their activation in response to lipopolysaccharide (LPS) stimulation. Accordingly, depletion of ARL11 impaired both LPS-stimulated pro-inflammatory cytokine production by macrophages and their ability to control intracellular replication of LPS-stimulated activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) was substantially compromised in -silenced macrophages.
View Article and Find Full Text PDFpolymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis.
Hered Cancer Clin Pract
June 2017
Department of Pharmaceuticals, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027 People's Republic of China.
Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1() might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer susceptibility is not completely consistent with polymorphisms, and the precise mechanism remains unknown. Therefore, we conducted a meta-analysis of case-control studies by searching the PubMed, Embase, OVID, Science Direct and Chinese National Knowledge Infrastructure (CNKI) databases.
View Article and Find Full Text PDFARLTS1, potential candidate gene in familial aggregation of hematological malignancies.
Bull Cancer
February 2017
Université de Sousse, faculté de médecine de Sousse, laboratoire de Biochimie, UR « biologie moléculaire des leucémies et lymphomes », avenue Mohamed Karoui, 4000 Sousse, Tunisia.
Article Synopsis
- The study investigates the genetic basis of familial hematological malignancies, focusing on the ARLTS1 gene, which has been linked to sporadic cancers.
- Researchers sequenced the ARLTS1 gene in 100 patients from 88 families in Tunisia and France, uncovering 8 genetic variations.
- Key findings show that variations like W149X and C148R are associated with increased risks for cancers, suggesting that ARLTS1 mutations could be important risk factors for familial hematological malignancies and related cancers.
ARLTS1 and prostate cancer risk--analysis of expression and regulation.
PLoS One
April 2014
Institute of Biomedical Technology/BioMediTech, University of Tampere and Fimlab Laboratories, Tampere, Finland.
Prostate cancer (PCa) is a heterogeneous trait for which several susceptibility loci have been implicated by genome-wide linkage and association studies. The genomic region 13q14 is frequently deleted in tumour tissues of both sporadic and familial PCa patients and is consequently recognised as a possible locus of tumour suppressor gene(s). Deletions of this region have been found in many other cancers.
View Article and Find Full Text PDFContribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.
PLoS One
February 2012
Institute of Biomedical Technology/BioMediTech, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland.
ARLTS1 is a recently characterized tumor suppressor gene at 13q14.3, a region frequently deleted in both sporadic and hereditary prostate cancer (PCa). ARLTS1 variants, especially Cys148Arg (T442C), increase susceptibility to different cancers, including PCa.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!