AI Article Synopsis
- A new alkaloid called 16 alpha-hydroxy-5 N-acetylardeemin was discovered from the fermentation broth of an endophytic fungus, ASPERGILLUS TERREUS, alongside seven known metabolites.
- The structures of these compounds were determined using detailed spectroscopic analysis and comparisons to existing data.
- The new compound demonstrated an inhibitory effect on the enzyme acetylcholinesterase, while all compounds displayed varying levels of cytotoxic activity against specific cell lines.
Article Abstract
One new alkaloid, named 16 alpha-hydroxy-5 N-acetylardeemin ( 1), along with seven known metabolites ( 2- 8) was isolated from the fermentation broth of an endophytic fungus, ASPERGILLUS TERREUS. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis and by comparing spectroscopic data with those in the literature. Compound 1 displayed an inhibitory effect against acetylcholinesterase. Compounds 1- 8 also showed moderate or weak cytotoxic activity against KB and HSC-T6 cell lines.
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