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Exploring Peripheral and Cardiac Immune Responses in a Pneumosepsis Mouse Model with Group A Streptococcus.
Am J Respir Cell Mol Biol
January 2025
Rostock University Medical Center, Institute of Medical Microbiology, Virology and Hygiene, Rostock, Germany.
(Group A Streptococcus, GAS) is a human pathogen that causes local and systemic infections of the skin and mucous membranes. However, GAS is also found asymptomatically in the nasopharynx of infants. GAS infections, including pharyngitis and invasive pneumosepsis, pose significant public health concerns.
View Article and Find Full Text PDFSex differences in treatment strategies for pulmonary embolism in older adults: The SERIOUS-PE study of RIETE participants and US Medicare beneficiaries.
Vasc Med
November 2024
Faculty of Health Sciences, UCAM Universidad Católica San Antonio de Murcia, Murcia, Spain.
Article Synopsis
- The study investigates sex differences in treatment approaches for pulmonary embolism (PE) among older adults, revealing that existing evidence on disparities is limited and often inconclusive due to small sample sizes and inadequate methods.
- Analysis of data from a European PE registry and US Medicare beneficiaries shows no significant overall sex differences in the use of anticoagulation or advanced therapies, although fewer women received fibrinolytic therapy compared to men with intermediate-risk PE.
- The authors suggest that future research should explore whether the observed sex disparities in treatment correlate with different clinical outcomes, especially regarding fibrinolytic therapy and advanced treatment utilization in older adults in the US.
Article Synopsis
- The study is a retrospective analysis investigating the effectiveness of single bolus cisternal urokinase in treating patients with saccular aneurysms and subarachnoid hemorrhages from January 2007 to December 2019.
- It found that administering urokinase during surgical clipping led to better outcomes in terms of reduced vasospasm, lower mortality rates, and fewer permanent CSF diversions compared to endovascular treatment methods, especially in patients with higher Fisher grades.
- Overall, the findings suggest that this treatment is safe and beneficial without significantly increasing complications like hemorrhages or infections.
Evaluation of coagulation by thromboelastography and a velocity curve in dogs with parvoviral enteritis.
Vet Med (Praha)
October 2024
Department of Internal Medicine, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey.
Article Synopsis
- The study investigates the coagulation status of dogs with canine parvoviral enteritis (CPE), a severe condition that can lead to high mortality due to systemic inflammation and multi-organ dysfunction.
- It involved 21 dogs diagnosed with CPE and 5 healthy controls, using thromboelastography (TEG) to analyze coagulation, showing significant differences in reaction times and clot dissolution rates.
- The findings suggest that TEG-derived velocity curve (v-curve) parameters could be a better method to assess coagulation in CPE cases, offering new insights for diagnosis and treatment strategies.
Prospective Application of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Disseminated Intravascular Coagulation.
Int J Nanomedicine
November 2024
Department of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Disseminated intravascular coagulation (DIC) is an acquired disorder characterized by systemic activation of blood coagulation, which can arise from various causes. Owing to its abrupt onset, rapid progression, and high mortality rate, DIC presents a major clinical challenge. Anticoagulant drugs, such as heparin or low-molecular-weight heparin, are the current gold standard of treatment; however, these interventions pose considerable bleeding risks.
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