Ethnopharmacological Relevance: Leaves of Cecropia pachystachya are described in the folk medicine as possessing antitusive, expectorant, antiasthmatic and hypoglycemic effects.
Aim Of The Study: To investigate the hypoglycemic and antioxidant effects of methanolic extract from the leaves of Cecropia pachystachya. The total amount of phenolic and flavonoids compounds was determined and the qualitative composition of the extract was analyzed.
Materials And Methods: The hypoglycemic effect of the extract was tested in normal, glucose loading and alloxan-induced diabetic rats. The antioxidant activity was assessed by DPPH free radical scavenging and reduction power assays. The total amount of phenolic and flavonoids compounds was determined by Folin-Denis and AlCl(3) reagent method, respectively. The qualitative composition of the extract was analyzed using a HPLC-DAD system.
Results: The glucose tolerance test showed that in diabetic rats, the extract caused a significant hypoglycemic effect with a blood glucose reduction of 68% after 12h. The administration of the extract in alloxan-induced diabetic rats also produced a significant reduction in the blood glucose levels at all points being more pronounced at 90min (reduction of 60%). After 120min, no significant difference was observed between the blood levels of the rats treated with the extract and those treated with the standard drugs (metformin and glibenclamide). The extract also presented relevant antioxidant activity with IC50=3.1microg/ml (DPPH assay) and EC50=10.8microg/ml (reduction power). Results were compared with the reference antioxidants quercetin, rutin, and ascorbic acid. The content of flavonoids was 83mg/g plant and that of phenolics was 326mg/g plant. Chlorogenic acid and the C-glycosylated flavones, orientin and isoorientin, were identified in the extract.
Conclusions: In conclusion, the findings showed that the folk medicinal plant Cecropia pachystachya possesses hypoglycemic and antioxidant effects which confirmed the traditional use of the plant in the treatment of diabetes. Chlorogenic acid and the C-glycosylated flavonoids may explain these activities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2010.01.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phytochemical diversity, therapeutic potential, and ecological roles of the genus.
Heliyon
December 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hafr Al Batin, P.O. Box 1803, Hafr Al Batin, 31991, Saudi Arabia.
The genus , a pivotal component of Neotropical flora, is renowned for its integration of traditional medicinal uses with significant ecological functions. This review aims to highlight the phytochemical diversity and pharmacological activities of the genus, with a particular focus on well-documented species such as , , and . Through a comprehensive review of the literature and current studies, this review identifies critical phytochemicals, including flavonoids, phenolic acids, and terpenoids, and correlates these compounds with biological activities such as anti-inflammatory, antimicrobial, and antioxidant effects.
View Article and Find Full Text PDFNutritive Value and Degradation Kinetic Parameters of Three Plants for Feeding Schinz, In Vitro Evaluation.
Animals (Basel)
September 2024
Departamento de Zootecnia, Universidade Federal Rural de Pernambuco, Recife 52171-900, PE, Brazil.
This study aimed to evaluate the nutritive value of three feeds ( sp., sp., and sp.
View Article and Find Full Text PDFInfluence of plant growth-promoting bacteria on leaf carbon and nitrogen metabolism of two drought-stressed neotropical tree species: a metabolomic approach.
Planta
June 2024
Department of Animal and Plant Biology, Center of Biological Sciences, State University of Londrina-UEL, Rodovia Celso Garcia Cid-PR445, Km 380, Campus Universitário, Londrina, PR, 86057-970, Brazil.
Deforestation of Atlantic Forest has caused prolonged drought events in the last decades. The need for reforestation is growing, and the development of native seedlings that are more tolerant to drought stress is necessary. A biotechnological tool that improves plant tolerance is the use of plant growth-promoting bacteria (PGPB) as inoculants.
View Article and Find Full Text PDFAntitumoral Activity of Cecropia Pachystachya Leaves Extract in Vitro and in Vivo Model of Rat Glioma: Brain and Blood Effects.
Mol Neurobiol
October 2024
Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, 96010-900, Brazil.
The aim of this study was to investigate the antiglioma effect of Cecropia pachystachya Trécul (CEC) leaves extract against C6 and U87 glioblastoma (GB) cells and in a rat preclinical GB model. The CEC extract reduced in vitro cell viability and biomass. In vivo, the extract decreased the tumor volume approximately 62%, without inducing systemic toxicity.
View Article and Find Full Text PDFProtective action of Cecropia pachystachya extract and enriched flavonoid fraction against memory deficits, inflammation and oxidative damage in lipopolysaccharide challenged mice.
J Ethnopharmacol
January 2024
Programa de Pós-Graduação Em Bioquímica e Bioprospecção, Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil. Electronic address:
Ethnopharmacological Relevance: Cecropia pachystachya (CP) Trécul is a medicinal plant native to South and Central America with several pharmacological properties, such as anti-inflammatory and neuroprotective.
Aim Of The Study: In this study, we investigated the effect of CP extract (200 mg/kg) and its enriched flavonoid fraction (EFF-CP) (50 and 100 mg/kg) in a model of lipopolysaccharide (LPS)-induced neuroinflammation.
Material And Methods: CP and EFF-CP were administered intragastrically for 14 days and LPS (250 μg/kg) was administered intraperitoneally from the 8th to the 14th days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!