AI Article Synopsis
- The study by Deans and West (2009) explores the molecular similarities between Fanconi Anemia and Bloom's Syndrome, which are genetic disorders affecting DNA repair.
- They identify FANCM as a key protein that connects the complexes responsible for each disorder, linking them at the DNA sites with interstrand crosslinks.
- This research enhances the understanding of how these diseases are related at a molecular level, potentially informing future therapeutic approaches.
Article Abstract
In this issue of Molecular Cell, Deans and West (2009) reveal the molecular basis of the phenotypic similarities between Fanconi Anemia (FA) and Bloom's Syndrome, identifying FANCM as the anchor for both FA and Bloom's complexes at the site of the DNA interstrand crosslink.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830608 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2009.12.007 | DOI Listing |
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