Background: We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source.
Methods: Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from 26 HIV-positive IDU samples.
Results: Our results showed formation of a tight monophyletic group with an intra-sequence identity of < 98% indicating a "founder effect". Our data indicate that the HIV-1 epidemic in this community of IDUs may have been transmitted by an HIV positive overseas contract worker who admitted to having contact with commercial sex workers during stay abroad.
Conclusion: Specific measures need to implemented to control transmission of HIV infection in Pakistan through infected migrant workers.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820481 | PMC |
| http://dx.doi.org/10.1186/1471-2334-10-7 | DOI Listing |
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