Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1182/blood-2009-10-249821 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unveiling the link between NADPH oxidase 2 activation and mitochondrial superoxide formation in leukemic cell killing induced by arsenic trioxide.
Pharmacol Res
December 2024
Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. Electronic address:
This study focused on the interplay between NADPH oxidase 2 (NOX 2) activation and mitochondrial superoxide (mitoO) formation induced by clinically relevant concentrations of arsenic trioxide (ATO; AsO) in acute promyelocytic leukemia (APL) cells. Carefully controlled inhibitor studies and small interfering RNA mediated downregulation of p47 (a component of the NOX 2 complex) expression demonstrated that, in an APL cell line, ATO promotes upstream NOX 2 activation critically connected with the formation of mitoO and with the ensuing mitochondrial permeability transition (MPT)-dependent apoptosis. Instead, acute myeloid leukemia (AML) cell lines respond to ATO with low NOX 2 activation, resulting in a state that is non-permissive for mitoO formation.
View Article and Find Full Text PDFGATA1 transcription factor targets the gene expression of B19 virus in HEK293 cell line.
Ann Med Surg (Lond)
December 2024
Department of Laboratory Hematology and Blood Banking, Dezful University of Medical Sciences, Iran.
Background/aim: B19 virus (B19V) is a single-strand DNA virus that has specific tropism to erythroid progenitor cells (EPCs). The virus enters the cells via P antigen and coreceptors and induces infection and cell apoptosis. GATA1 has a high expression in EPC and is a critical transcription factor for the cells development and differentiation.
View Article and Find Full Text PDFExtracellular vesicles from fifth-stage larval upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocytes.
mSystems
December 2024
Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei City, Taiwan.
is a zoonotic parasite that causes severe symptoms in humans, including eosinophilic meningitis and eosinophilic meningoencephalitis. Extracellular vesicles (EVs) derived from helminthes have been implicated in regulating host survival and immune response. However, the roles of EVs in modulating parasite pathogenesis and host immune response remain poorly understood.
View Article and Find Full Text PDFTransgenerational Sterility of a Transgenic : A Cautionary Tale.
MicroPubl Biol
November 2024
Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States.
The integration of fluorescent protein tags (GFP, mScarlet, mNeon, etc) by CRISPR is often inefficient due to the size of the tags (hundreds of base pairs). To facilitate fluorescent tagging, the split-GFP and split-Scarlet systems have been optimized for use in (Goudeau et al., 2021).
View Article and Find Full Text PDFThe neonatal Fc receptor is a cellular receptor for human astrovirus.
Nat Microbiol
December 2024
Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Human astroviruses (HAstV) are major causes of gastroenteritis, especially in children, and there are no vaccines or antivirals currently available. Little is known about host factors required for their cellular entry. Here we utilized complementary CRISPR-Cas9-based knockout and activation screens to identify neonatal Fc receptor (FcRn) and dipeptidyl-peptidase IV (DPP4) as entry factors for HAstV infection in vitro.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!