Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.
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Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Germany.
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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
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