Background: Lipid accretion is one of the major side effects of clozapine pharmacotherapy of schizophrenia that made clozapine into an interesting obesity drug model.
Method: Ingenuity Pathway Analysis (IPA) engine was used for core analysis and building the networks of weight regulation.
Results: The examination of molecules that were selected into 'clozapine neighborhood' identified them as multifunctional signals that appear to orchestrate vascular and tissue functions plausibly implicated in adiposity side effect.
Conclusions: It is hypothesized that clozapine unmasks the functional and morphological phenotype of microvascular deficit that facilitates shunting nutrients from utilization toward storage.
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| http://dx.doi.org/10.1159/000127278 | DOI Listing |
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