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Death-associated protein kinase-mediated cell death modulated by interaction with DANGER. | LitMetric

Death-associated protein kinase (DAPK) is a key player in multiple cell death signaling pathways. We report that DAPK is regulated by DANGER, a partial MAB-21 domain-containing protein. DANGER binds directly to DAPK and inhibits DAPK catalytic activity. DANGER-deficient mouse embryonic fibroblasts and neurons exhibit greater DAPK activity and increased sensitivity to cell death stimuli than do wild-type control cells. In addition, DANGER-deficient mice manifest more severe brain damage after acute excitotoxicity and transient cerebral ischemia than do control mice. Accordingly, DANGER may physiologically regulate the viability of neurons and represent a potential therapeutic target for stroke and neurodegenerative diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840720PMC
http://dx.doi.org/10.1523/JNEUROSCI.3974-09.2010DOI Listing

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