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COMT ValMet polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children.
Eur J Neurosci
December 2024
Post-Graduated Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Article Synopsis
- Childhood trauma negatively affects mental health and can be passed down to future generations, impacting the emotional and behavioral issues of children.
- The study analyzed 310 preschool-aged children to see how maternal childhood trauma interacted with genetic factors, specifically the COMT ValMet variant, and assessed behavioral problems using established questionnaires.
- Results showed that while maternal trauma generally increases behavioral issues in children, those with the Val/Met genotype are less prone to certain problems compared to those with other genetic variants, highlighting the importance of both trauma and genetics in child development.
Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.
Neurobiol Aging
February 2025
Department of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States. Electronic address:
Dopamine (DA) signaling is critical for optimal cognitive aging, especially in prefrontal-parietal and fronto-striatal networks. Single nucleotide polymorphisms associated with dopamine regulation, COMTVal158Met and DRD2C957T, stand to exert influence on executive function performance via neural properties. The current study investigated whether longitudinal thinning of mesocortical regions is related to COMT and DRD2 genetic predisposition and associated with decline in executive function over four-years.
View Article and Find Full Text PDFCognitive Impairments Related to COMT and Neuregulin 1 Phenotypes as Transdiagnostic Markers in Schizophrenia Spectrum Patients.
J Clin Med
October 2024
Discipline of Medical Genetics, Department of Microscopic Morphology, Center of Genomic Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Research on the interaction between antipsychotic treatment and cognitive dysfunction in schizophrenia spectrum disorders (SSDs) is extensive, yet the role of genetic polymorphisms in catechol-O-methyltransferase (COMT) and neuregulin 1 (NRG1) remains underexplored. : This study evaluates the impact of COMT (rs4680) and NRG1 (rs3924999 and rs35753505) polymorphisms on cognitive functions in SSD patients. A cross-sectional study was conducted with fifty-four patients, assessed using the Positive and Negative Syndrome Scale (PANSS) and the CNS Vital Signs battery.
View Article and Find Full Text PDFExploring Nanocarriers for Boosting Entacapone Bioavailability: A Journey through System Characterization and Assessment of Toxicity and Pharmacological and 2D Permeability Paybacks.
ACS Appl Mater Interfaces
October 2024
CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
Catechol--methyltransferase inhibitors (iCOMT), such as entacapone, have been successfully employed to treat tremor-related symptoms of Parkinson's disease. However, iCOMT has been associated with a short half-life and poor oral bioavailability. Nanobased drug delivery systems have often been used to overcome this type of setbacks.
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