Today, a growing number of people, some of them suffering from lung diseases, travel to high altitude resorts. It is sometimes not easy for the general practitioner to adequately counsel these patients. Based on our knowledge of physiopathology and clinical studies, the present paper addresses the effects of high altitude in patients with preexisting lung diseases and provides recommendations in order to optimize the sojourn at high altitude.
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Signal Transduct Target Ther
December 2024
Department of Orthopedic Surgery/Sports Medicine Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
Metabolites can double as a signaling modality that initiates physiological adaptations. Metabolism, a chemical language encoding biological information, has been recognized as a powerful principle directing inflammatory responses. Cytosolic pH is a regulator of inflammatory response in macrophages.
View Article and Find Full Text PDFFront Plant Sci
December 2024
Qilu Normal University, School of Geography and Tourism, Jinan, Shandong, China.
Aims: Understanding the response of herbaceous plants to habitat changes and the mechanisms of vegetation succession is crucial to the theoretical foundation of the conservation of local vegetation.
Methods: Plots were established at elevations of 1900-2200m, 2200-2500m, and 2500-2800m on both shady and sunny slopes. Four statistical methods 2×2 contingency table χ-test, Spearman's rank correlation coefficient, AC joint coefficient, 17 and Ochiai Index, were employed to analyze the species composition and interspecific associations within each elevation band and aspect.
Med J Armed Forces India
December 2024
Clinical Tutor, Department of Internal Medicine, Armed Forces Medical College, C/o 56 APO, India.
High altitude pulmonary oedema (HAPO) is a common emergency seen at high altitude. It can be associated with electrocardiogram (ECG) changes due to pulmonary arterial hypertension in the form of ST elevation and T wave inversion in the right precordial leads, which mimic acute coronary syndrome. These changes can lead to confusion in diagnosis and management.
View Article and Find Full Text PDFTrends Genet
December 2024
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel. Electronic address:
Adaptation to environmental conditions occurs over diverse evolutionary timescales. In multi-cellular organisms, adaptive traits are often studied in tissues/organs relevant to the environmental challenge. We argue for the importance of an underappreciated layer of evolutionary adaptation manifesting at the cellular level.
View Article and Find Full Text PDFCompr Rev Food Sci Food Saf
January 2025
Center of High Altitude Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Furan (C₄H₄O), an unintended hazardous compound, is formed in various thermally processed foods through multiple pathways, raising concerns due to its potential carcinogenicity in humans. The aim of this comprehensive review was to synthesize and evaluate the latest research on furan, from its formation by different precursors to its presence in diverse food matrices, as well as the emerging methods for its detection and mitigation. Emphasizing the toxicity of furan, it explored evidence from in vitro and in vivo studies, including reproductive toxicity, carcinogenic effects, and related biomarkers.
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