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Dealing with the remaining controversies of probiotic safety.

Benef Microbes

July 2019

Athena Institute, VU Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.

A clear safety profile of probiotics in clinical practice is essential in decision-making for all stakeholders and regulators. Probiotics have been investigated in different target populations, conditions and age groups. This also includes the use of probiotics in critically ill patients.

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Purpose Of Review: To summarize the existing data regarding the use of probiotics, prebiotics, and synbiotics in select disorders encountered in the intensive care unit setting.

Recent Findings: Recent systematic reviews and meta-analyses have more rigorously aggregated the fragmented primary data which suffers from multiple limitations.

Summary: Probiotics are living microorganisms which, when ingested in adequate amounts, provide health benefits to the host.

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Synbiotics and probiotics in the critically ill after the PROPATRIA trial.

Curr Opin Clin Nutr Metab Care

March 2012

Division of Pulmonary, Critical Care and Sleep Medicine, Nebraska, USA.

Purpose Of Review: Recent clinical trials have furthered our understanding of the role of probiotic and synbiotic therapy across a variety of diverse diseases including antibiotic-associated diarrhea, Clostridium difficile associated diarrhea, acute pancreatitis, ventilator-associated pneumonia, and sepsis among others. Although each of these conditions has implications for critically ill patients, relatively few studies have specifically studied this vulnerable population.

Recent Findings: One recent clinical trial studying probiotics in severe pancreatitis (the PROPATRIA trial) found an unexpected increase in mortality in probiotic-treated patients.

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