Pentoxifilne (PTX) is a non specific inhibitor of cytokines release, which suppress mainly TNF production. The aim of this study was to evaluate behavioural activity changes in response to acute and chronic nociceptive stimulus. PTX was more effective in neuropathic pain than acute pain model. Use of cytokine inhibitors might offer new strategies of drug-resistant chronic pain treatment.
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[Role of pendoxifiline (PTX) in different and cute and chronic models of pain in rats].
Folia Med Cracov
February 2010
Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland.
Pentoxifilne (PTX) is a non specific inhibitor of cytokines release, which suppress mainly TNF production. The aim of this study was to evaluate behavioural activity changes in response to acute and chronic nociceptive stimulus. PTX was more effective in neuropathic pain than acute pain model.
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