The objective of the current study was to determine tablet content and perform dissolution test of expired tablets and tablets which expiry date has not exceeded. The analyzed tablets contained metoprolol tartrate (50 mg) and propranolol hydrochloride (10 mg), respectively. Content determination was performed using spectrophotometric method with UV detection; the percent of dissolved substance from tablets during dissolution test was performed using spectrophotometric method, as well. The proposed methods were validated with regard to linearity, sensitivity, and intermediate accuracy and precision. No discrepancies between the results of determination and the declared values range for all the analyzed tablets were observed. The results of performed study might suggest that the storage of analyzed batches of tablets over time period exceeding the expiry date given by the manufacturer did not influence their contents.
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