The purpose of the study was to evaluate the efficiency of fluography (FLG) as a technique for the timely detection of cases of pulmonary tuberculosis in an investigatory isolation ward. According to the WHO data, at early detection stages the bacteria-discharging persons should constitute about 80% of all cases. Analysis of the first FLG films made in 22,973 prisoners in 2005-2007 revealed abnormalities in 7.6% of the convicts and tuberculosis-associated changes in 77% of cases. Sputum smear luminescence microscopy and culture for Mycobacterium tuberculosis in 115 patients showed that the persons who discharged bacteria were 72.2% of the patients. The data suggest that FLG is highly effective in timely identifying cases of pulmonary tuberculosis.
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Lung
January 2025
Department of Medicine, National University Hospital, NUHS Tower Block, Level 10, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Purpose: Tuberculosis (TB) is a highly contagious infection and one of the world's leading causes of death from a single infectious agent. Currently, TB diagnosis can be established via mycobacterial cultures, Acid Fast Bacilli smear and molecular studies. In the ever-evolving landscape of medical advancements, breath tests have shown considerable promise.
View Article and Find Full Text PDFLancet Reg Health Am
November 2024
Programa Pós-graduação de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Background: Tuberculosis (TB) remains a global challenge and disproportionately affecting vulnerable populations. This study analyses the economic burden of pulmonary TB in Brazil, focusing on direct healthcare costs. It also evaluates the cost-effectiveness of the Directly Observed Treatment (DOT) strategy and the economic effort required to achieve a 90% probability of cure.
View Article and Find Full Text PDFFront Public Health
January 2025
Institute of Occupational Health and Environmental Health, School of Public Health, Lanzhou University, Lanzhou, China.
Introduction: The primary aim of this study is to investigate and predict the prevalence and determinants of tuberculosis disease burden in China. Leveraging high-quality data sources and employing a methodologically rigorous approach, the study endeavors to enhance our understanding of tuberculosis control efforts across different regions of China. First, through nationwide spatio-temporal cluster analysis, we summarized the status of tuberculosis burden in various regions of China and explore the differences, thereby providing a basis for formulating more targeted tuberculosis prevention and control policies in different regions; Subsequently, using a time series-based forecasting model, we conducted the first-ever national tuberculosis burden trend forecast to offer scientific guidance for timely adjustments in planning and resource allocation.
View Article and Find Full Text PDFJ Biol Methods
October 2024
Indian Council of Medical Research-National Institute of Occupational Health, Ahmedabad, Gujarat 380016, India.
Background: Earlier studies conducted by Indian researchers have demonstrated that the elimination of tuberculosis (TB) requires proactive control of silicosis, given India's significant burden of silicosis and its common comorbidity, pulmonary TB, also known as silicotuberculosis. The TB Control Indian Health Authority saw human immunodeficiency virus infection, diabetes, and malnutrition, among others, as important risk factors for case findings, but overlooked the significance of silicosis. Silicotuberculosis control is often confronted with challenges of detecting microorganisms, uncertain treatment outcomes, a higher likelihood of mono-drug and multi-drug resistance, and increased mortality due to treatment failure.
View Article and Find Full Text PDFMonaldi Arch Chest Dis
January 2025
Department of Community Medicine, K.S. Hegde Medical College, Deralakatte, Karnataka.
The term "asthma-chronic obstructive pulmonary disease (COPD) combined phenotype" describes patients with persistent airflow limitation and features of both asthma and COPD. There is a lack of data on effective treatments for this group, often excluded from asthma or COPD trials. Inhaled corticosteroids (ICS) are standard for asthma, while bronchodilators are key for COPD.
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