AI Article Synopsis
- Sustained virologic suppression is crucial for treating chronic hepatitis B, and a study showed that after 48 weeks of entecavir therapy, it was more effective than lamivudine for HBeAg-positive patients.
- In a follow-up study with 183 patients, those who continued entecavir for up to 5 years showed impressive results, with 94% having low HBV DNA levels and 80% maintaining normal ALT levels.
- Overall, prolonged entecavir treatment not only preserved viral suppression but also led to more patients achieving HBeAg loss and seroconversion, with minimal resistance reported.
Article Abstract
Unlabelled: Sustained virologic suppression is a primary goal of therapy for chronic hepatitis B (CHB). In study entecavir (ETV)-022, 48 weeks of entecavir 0.5 mg was superior to lamivudine for virologic suppression for hepatitis B e antigen (HBeAg)-positive CHB. A total of 183 entecavir-treated patients from ETV-022 subsequently enrolled in study ETV-901. We present the results after up to 5 years (240 weeks) of continuous entecavir therapy. The entecavir long-term cohort consists of patients who received >or=1 year of entecavir 0.5 mg in ETV-022 and then entered ETV-901 with a treatment gap
Conclusion: Extended therapy with entecavir through 5 years maintained or increased rates of HBV DNA suppression and ALT normalization. Additional patients also achieved HBeAg loss and seroconversion. Entecavir provides sustained viral suppression with minimal resistance during long-term treatment of HBeAg-positive CHB.
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| http://dx.doi.org/10.1002/hep.23327 | DOI Listing |
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